COG1 Gene Summary [Human]
The protein encoded by this gene is one of eight proteins (Cog1-8) which form a Golgi-localized complex (COG) required for normal Golgi morphology and function. It is thought that this protein is required for steps in the normal medial and trans Golgi-associated processing of glycoconjugates and plays a role in the organization of the Golgi-localized complex. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | COG1 |
| Official Name | component of oligomeric golgi complex 1 [Source:HGNC Symbol;Acc:HGNC:6545] |
| Ensembl ID | ENSG00000166685 |
| Bio databases IDs | |
| Aliases | component of oligomeric golgi complex 1 |
| Synonyms | 6030445I15, CDG2G, component of oligomeric golgi complex 1, DT1P1E11, LDLB, mKIAA1381 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human COG1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- central domain
- protein binding
- Vps51/Vps67
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi Apparatus
- cytosol
- Golgi membrane
- trans Golgi network
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human COG1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glycosylation
- Golgi organization
- protein transport
- intra-Golgi vesicle-mediated transport
- retrograde transport, vesicle recycling within Golgi
Cellular Component
Where in the cell the gene product is active
- Golgi transport complex
- Golgi membrane
- Golgi apparatus
- trans-Golgi network membrane
Molecular Function
What the gene product does at the molecular level
- protein binding