POSTN Gene Summary [Human]
This gene encodes a secreted extracellular matrix protein that functions in tissue development and regeneration, including wound healing, and ventricular remodeling following myocardial infarction. The encoded protein binds to integrins to support adhesion and migration of epithelial cells. This protein plays a role in cancer stem cell maintenance and metastasis. Mice lacking this gene exhibit cardiac valve disease, and skeletal and dental defects. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]
Details
| Type | Protein Coding |
| Official Symbol | POSTN |
| Official Name | periostin [Source:HGNC Symbol;Acc:HGNC:16953] |
| Ensembl ID | ENSG00000133110 |
| Bio databases IDs | |
| Aliases | periostin, osteoblast specific factor 2 |
| Synonyms | A630052E07RIK, FLJ11382, OSF-2, OSF-2P1, Osteoblast-Specific Factor2, PDLPOSTN, Periostin, periostin, osteoblast specific factor, PLF, PN |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human POSTN often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Fasciclin domain
- FAS1 domain
- signal peptide
- metal ion binding
- protein binding
- heparin binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- neoplasia
- lung cancer
- knee osteoarthritis
- heart disease
- diabetic nephropathy
- organismal death
- ovarian serous cystadenocarcinoma
- serous ovarian cancer
- lung metastasis
role in cell
- proliferation
- signaling in
- expression in
- phosphorylation in
- growth
- quantity
- cell viability
- migration
- adhesion
- morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- S-layer
- perinuclear region
- trans Golgi network
- neuromuscular junctions
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human POSTN gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to muscle activity
- regulation of Notch signaling pathway
- regulation of systemic arterial blood pressure
- cellular response to fibroblast growth factor stimulus
- negative regulation of substrate adhesion-dependent cell spreading
- cell adhesion
- tissue development
- response to mechanical stimulus
- cellular response to transforming growth factor beta stimulus
- response to hypoxia
- negative regulation of cell-matrix adhesion
- response to estradiol stimulus
- extracellular matrix organization
- positive regulation of chemokine (C-X-C motif) ligand 2 production
- cellular response to tumor necrosis factor
- positive regulation of smooth muscle cell migration
- cellular response to vitamin K
Cellular Component
Where in the cell the gene product is active
- extracellular space
- trans-Golgi network
- neuromuscular junction
- extracellular matrix
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- cell adhesion molecule binding
- heparin binding
- extracellular matrix structural constituent