LRRCC1 Gene Summary [Human]
This gene encodes a centrosomal protein that maintains the structural integrity of the centrosome and plays a key role in mitotic spindle formation. The encoded protein contains an N-terminal leucine-rich repeat domain and a C-terminal coiled-coil domain. It associates with the centrosome throughout the cell cycle and accumulates on the mitotic centrosome. [provided by RefSeq, Mar 2017]
Details
| Type | Protein Coding |
| Official Symbol | LRRCC1 |
| Official Name | leucine rich repeat and coiled-coil centrosomal protein 1 [Source:HGNC Symbol;Acc:HGNC:29373] |
| Ensembl ID | ENSG00000133739 |
| Bio databases IDs | |
| Aliases | leucine rich repeat and coiled-coil centrosomal protein 1, centrosomal leucine-rich repeat and coiled-coil containing protein, variable number of flagella 1 homolog (Chlamydomonas) |
| Synonyms | 1200008A14Rik, 4932441F23Rik, CLERC, CLERK, leucine rich repeat and coiled-coil centrosomal protein 1, leucine rich repeat and coiled-coil domain containing 1, LOC678993, LOC686123, SAP2, VFL1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human LRRCC1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein phosphatase 1 regulatory subunit 42
- Ciliary protein causing Leber congenital amaurosis disease
- Hyaluronan mediated motility receptor N-terminal
- Synaptonemal complex protein 1 (SCP-1)
- Growth-arrest specific micro-tubule binding
- Leucine rich repeat
- helix-rich Mycoplasma protein
- Leucine Rich repeats (2 copies)
- Calcium binding and coiled-coil domain (CALCOCO1) like
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- centrosome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human LRRCC1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
Cellular Component
Where in the cell the gene product is active
- centrosome
- centriole
- cytoplasm