ARL8B Gene Summary [Human]
Enables guanyl ribonucleotide binding activity and tubulin binding activity. Involved in several processes, including calcium ion regulated lysosome exocytosis; lysosomal transport; and vesicle fusion. Located in cytolytic granule membrane; midbody; and spindle midzone. Colocalizes with lysosomal membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | ARL8B |
| Official Name | ADP ribosylation factor like GTPase 8B [Source:HGNC Symbol;Acc:HGNC:25564] |
| Ensembl ID | ENSG00000134108 |
| Bio databases IDs | |
| Aliases | ADP ribosylation factor like GTPase 8B, GTPase indispensable for equal segregation of chromosomes 1 |
| Synonyms | 2610313E07Rik, 3100002J04RIK, ADP-ribosylation factor-like 8B, ARF like GTPase 8B, ARL10C, Gie1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ARL8B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- beta-tubulin binding
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- Ras family
- small monomeric GTPase
- GTPase
- enzyme
- protein binding
- Ras subfamily of RAS small GTPases
- GTP binding
- ADP-ribosylation factor family
- small GTP-binding protein domain
- GDP binding
- alpha-tubulin binding
- Ras of Complex, Roc, domain of DAPkinase
- ADP-ribosylation factor
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the ARL8B gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- preeclampsia
- periodontitis
- degeneration of lumbar intervertebral disc
regulates
- blood urea nitrogen
- MHC II (complex)
- Shiga toxin 2
role in cell
- accumulation in
- quantity
- fusion
- accumulation
- localization
- cytotoxicity
- antigen presentation in
- fusion in
- transport
- dynamics
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- pH resistant lipid raft fraction
- Cytoplasm
- perinuclear region
- lysosome
- midbody
- cytosol
- lysosome membrane
- endosomal membrane
- synaptic vesicles
- synapse
- central spindle
- axons
- autophagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ARL8B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- endosome to lysosome transport of low-density lipoprotein particle
- anterograde axon cargo transport
- protein transport
- non-lytic viral exocytosis
- phagosome-lysosome fusion
- chromosome segregation
- natural killer cell mediated cytotoxicity
- lysosome localization
- cell division
- plasma membrane repair
- antigen processing and presentation of polysaccharide antigen via MHC class II
- antigen processing and presentation following phagocytosis
- early endosome to Golgi transport
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- late endosome membrane
- spindle midzone
- extracellular vesicular exosome
- cytoplasm
- membrane
- cytosol
- synapse
- midbody
- lysosomal membrane
- lysosome
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- GTPase activity
- beta-tubulin binding
- small monomeric GTPase activity
- GDP binding
- alpha-tubulin binding