PSRC1 Gene Summary [Human]
This gene encodes a proline-rich protein that is a target for regulation by the tumor suppressor protein p53. The encoded protein plays an important role in mitosis by recruiting and regulating microtubule depolymerases that destabalize microtubules. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Apr 2014]
Details
| Type | Protein Coding |
| Official Symbol | PSRC1 |
| Official Name | proline and serine rich coiled-coil 1 [Source:HGNC Symbol;Acc:HGNC:24472] |
| Ensembl ID | ENSG00000134222 |
| Bio databases IDs | |
| Aliases | proline and serine rich coiled-coil 1, differential display and activated by p53 |
| Synonyms | 5430413I02Rik, DDA3, FP3214, LOC684669, proline and serine rich coiled-coil 1, proline/serine-rich coiled-coil 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PSRC1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- microtubule binding
- G-2 and S-phase expressed 1
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- coronary artery disease
- lung adenocarcinoma
- lung adenocarcinoma formation
- coronary disease
- organismal death
regulates
- LDL
role in cell
- formation
- growth
- organization
- movement
- colony formation
- polymerization
- misalignment in
- misalignment
- polymerization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubule cytoskeleton
- spindle apparatus
- midbody
- cytosol
- nucleoplasm
- spindle pole
- spindle fibers
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PSRC1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- positive regulation of cyclin-dependent protein kinase activity
- microtubule bundle formation
- negative regulation of cell growth
- positive regulation of transcription, DNA-dependent
- positive regulation of microtubule polymerization
- regulation of mitotic spindle organization
- mitotic metaphase plate congression
Cellular Component
Where in the cell the gene product is active
- spindle microtubule
- microtubule cytoskeleton
- cytoplasm
- spindle pole
- spindle
- cytosol
- midbody
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- microtubule binding