PRMT2
PRMT2 Gene Summary
Enables several functions, including nuclear receptor binding activity; peroxisome proliferator activated receptor binding activity; and protein homodimerization activity. Involved in several processes, including histone methylation; regulation of androgen receptor signaling pathway; and regulation of transcription, DNA-templated. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | PRMT2 |
| Official Name | protein arginine methyltransferase 2 [Source:HGNC Symbol;Acc:HGNC:5186] |
| Ensembl ID | ENSG00000160310 |
| Bio databases IDs | |
| Aliases | protein arginine methyltransferase 2 |
| Synonyms | HRMT1L1,LOC102549829,protein arginine methyltransferase 2,protein arginine N-methyltransferase 2 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ligand-dependent nuclear receptor interactor
- transcription co-activator
- beta-catenin binding
- retinoic acid receptor binding
- androgen receptor binding
- enzyme
- estrogen receptor binding
- protein binding
- AdoMet_MTases
- thyroid hormone receptor binding
- protein-arginine N-methyltransferase
- methyltransferase domain
- Src Homology 3 domain superfamily
- S-adenosylmethionine binding domain
- histone methyltransferase
- peroxisome proliferator activated receptor binding
- binding protein
- protein homodimerization
Pathways
Biological processes and signaling networks where the PRMT2 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- ESR2
- HTT
- HNRNPK
- GTF2H1
- ESR1
- PPARG
- RIPK2
- ERF
- TTC28
- HNRNPA1
disease
- metastasis
- renal cell cancer
- neoplasia
- breast cancer
- organismal death
- renal cancer
- airway hyperresponsiveness
- breast adenocarcinoma
- idiopathic scoliosis
- diverticular disease
regulated by
- PTEN
- estrogen
- Influenza A virus (A/Bangkok/RX73(H3N2))
- LY-411,575
- valproic acid
- KLF3
- PAX3
- TK1
- PIWIL4
- aflatoxin B1
regulates
- RELA
- CDH1
- IL6
- TNF
- NFkB (complex)
- reporter gene
- DNA promoter
- DNA endogenous promoter
- ESR1
- TAT
role in cell
- apoptosis
- binding in
- accumulation in
- expression in
- proliferation
- invasion by
- migration
- recruitment
- transactivation in
- activation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- perinuclear region
- cytosol
- nucleoplasm
- nucleoli
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the PRMT2 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- chromatin remodeling
- developmental cell growth
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- negative regulation of NF-kappaB transcription factor activity
- signal transduction
- peptidyl-arginine methylation, to asymmetrical-dimethyl arginine
- positive regulation of apoptotic process
- negative regulation of G1/S transition of mitotic cell cycle
- protein methylation
- regulation of androgen receptor signaling pathway
CELLULAR COMPONENT
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- nucleolus
- nucleoplasm
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein-arginine omega-N asymmetric methyltransferase activity
- protein homodimerization activity
- progesterone receptor binding
- retinoic acid receptor binding
- peroxisome proliferator activated receptor binding
- thyroid hormone receptor binding
- protein binding
- transcription coactivator activity
- androgen receptor binding
- histone methyltransferase activity
- protein-arginine N-methyltransferase activity
- estrogen receptor binding