PRMT2 Gene Summary

Enables several functions, including nuclear receptor binding activity; peroxisome proliferator activated receptor binding activity; and protein homodimerization activity. Involved in several processes, including histone methylation; regulation of androgen receptor signaling pathway; and regulation of transcription, DNA-templated. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

Details

Type
Protein Coding
Official Symbol
PRMT2
Official Name
protein arginine methyltransferase 2 [Source:HGNC Symbol;Acc:HGNC:5186]
Ensembl ID
ENSG00000160310
Bio databases IDs NCBI: 3275 Ensembl: ENSG00000160310
Aliases protein arginine methyltransferase 2
Synonyms
HRMT1L1,LOC102549829,protein arginine methyltransferase 2,protein arginine N-methyltransferase 2
Species
Human, Homo sapiens

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • ligand-dependent nuclear receptor interactor
  • transcription co-activator
  • beta-catenin binding
  • retinoic acid receptor binding
  • androgen receptor binding
  • enzyme
  • estrogen receptor binding
  • protein binding
  • AdoMet_MTases
  • thyroid hormone receptor binding
  • protein-arginine N-methyltransferase
  • methyltransferase domain
  • Src Homology 3 domain superfamily
  • S-adenosylmethionine binding domain
  • histone methyltransferase
  • peroxisome proliferator activated receptor binding
  • binding protein
  • protein homodimerization

Pathways

Biological processes and signaling networks where the PRMT2 gene plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • metastasis
  • renal cell cancer
  • neoplasia
  • breast cancer
  • organismal death
  • renal cancer
  • airway hyperresponsiveness
  • breast adenocarcinoma
  • idiopathic scoliosis
  • diverticular disease
regulated by
  • PTEN
  • estrogen
  • Influenza A virus (A/Bangkok/RX73(H3N2))
  • LY-411,575
  • valproic acid
  • KLF3
  • PAX3
  • TK1
  • PIWIL4
  • aflatoxin B1
regulates
role in cell
  • apoptosis
  • binding in
  • accumulation in
  • expression in
  • proliferation
  • invasion by
  • migration
  • recruitment
  • transactivation in
  • activation in

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Nucleus
  • Cytoplasm
  • perinuclear region
  • cytosol
  • nucleoplasm
  • nucleoli
  • plasma

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the PRMT2 gene, providing context for its role in the cell.

biological PROCESS

Functions and activities the gene product is involved in
  • chromatin remodeling
  • developmental cell growth
  • negative regulation of transcription, DNA-dependent
  • positive regulation of transcription, DNA-dependent
  • negative regulation of NF-kappaB transcription factor activity
  • signal transduction
  • peptidyl-arginine methylation, to asymmetrical-dimethyl arginine
  • positive regulation of apoptotic process
  • negative regulation of G1/S transition of mitotic cell cycle
  • protein methylation
  • regulation of androgen receptor signaling pathway

cellular COMPONENT

Where in the cell the gene product is active
  • nucleus
  • cytoplasm
  • cytosol
  • nucleolus
  • nucleoplasm

molecular FUNCTION

What the gene product does at the molecular level
  • protein-arginine omega-N asymmetric methyltransferase activity
  • protein homodimerization activity
  • progesterone receptor binding
  • retinoic acid receptor binding
  • peroxisome proliferator activated receptor binding
  • thyroid hormone receptor binding
  • protein binding
  • transcription coactivator activity
  • androgen receptor binding
  • histone methyltransferase activity
  • protein-arginine N-methyltransferase activity
  • estrogen receptor binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.