RPS15A Gene Summary [Human]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S8P family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

Details

Type
Protein Coding
Official Symbol
RPS15A
Official Name
ribosomal protein S15a [Source:HGNC Symbol;Acc:HGNC:10389]
Ensembl ID
ENSG00000134419
Bio databases IDs NCBI: 6210 Ensembl: ENSG00000134419
Aliases ribosomal protein S15a
Synonyms A630031B11Rik, AU043390, DBA20, ribosomal protein S15A, S15a, uS8
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RPS15A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Ribosomal protein S8
  • structural constituent of ribosome
  • protein binding

Pathways

Biological processes and signaling networks where the RPS15A gene in human plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • diabetes mellitus
  • myelodysplastic syndrome
  • metabolic syndrome X
  • Diamond-Blackfan anemia type 20
  • aortic valve calcification
regulated by
regulates
role in cell
  • expression in
  • cell death
  • proliferation
  • cell cycle progression
  • migration
  • processing in
  • invasion by
  • translation in
  • beta-catenin signaling in
  • Wnt signaling in

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • pre-ribosome
  • ribosome
  • cytosol
  • nucleoplasm
  • nucleoli
  • synapse

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human RPS15A gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • cytoplasmic translation
  • positive regulation of cell proliferation
  • ribosomal small subunit biogenesis
  • positive regulation of cell cycle
  • response to virus
  • translation

Cellular Component

Where in the cell the gene product is active
  • small-subunit processome
  • extracellular vesicular exosome
  • cytosolic ribosome
  • cytosolic small ribosomal subunit
  • cytoplasm
  • membrane
  • cytosol
  • synapse
  • nucleolus
  • nucleoplasm

Molecular Function

What the gene product does at the molecular level
  • protein binding
  • RNA binding
  • structural constituent of ribosome

Gene-Specific Assays for Results You Can Trust

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