METTL14 Gene Summary [Human]
Enables mRNA binding activity. Contributes to mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity. Involved in mRNA metabolic process; negative regulation of hematopoietic progenitor cell differentiation; and positive regulation of translation. Located in nucleoplasm. Part of RNA N6-methyladenosine methyltransferase complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | METTL14 |
| Official Name | methyltransferase like 14 [Source:HGNC Symbol;Acc:HGNC:29330] |
| Ensembl ID | ENSG00000145388 |
| Bio databases IDs | |
| Aliases | methyltransferase like 14, methyltransferase 14, N6-adenosine-methyltransferase subunit |
| Synonyms | G430022H21Rik, hMETTL14, methyltransferase 14, N6-adenosine-methyltransferase non-catalytic subunit, methyltransferase 14, N6-adenosine-methyltransferase subunit, mKIAA1627, RGD1304822 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human METTL14 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- MT-A70
- mRNA (N6-adenosine)-methyltransferase
- mRNA binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- liver cancer
- female infertility
- tumorigenesis
- metastasis
- squamous-cell carcinoma
- squamous cell cancer
- focal segmental glomerulosclerosis
- glioblastoma
- glioblastoma cancer
role in cell
- phosphorylation in
- proliferation
- apoptosis
- migration
- expression in
- activation in
- degradation in
- binding
- stabilization in
- autophagy in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human METTL14 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- stem cell maintenance
- mRNA destabilization
- positive regulation of translation
- spermatogenesis
- mRNA processing
- regulation of neuron differentiation
- mRNA catabolic process
- forebrain radial glial cell differentiation
- nuclear mRNA splicing, via spliceosome
- RNA methylation
- gliogenesis
- mRNA stabilization
- mRNA modification
Cellular Component
Where in the cell the gene product is active
- nucleus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- mRNA (N6-adenosine)-methyltransferase activity
- mRNA binding