Rps15a Gene Summary [Mouse]
A structural constituent of ribosome. Predicted to be involved in several processes, including positive regulation of cell population proliferation; response to virus; and ribosomal small subunit biogenesis. Located in mitochondrion. Part of cytosolic small ribosomal subunit. Is active in synapse. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 20. Orthologous to human RPS15A (ribosomal protein S15a). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rps15a |
| Official Name | ribosomal protein S15A [Source:MGI Symbol;Acc:MGI:2389091] |
| Ensembl ID | ENSMUSG00000008683 |
| Bio databases IDs | |
| Aliases | ribosomal protein S15A |
| Synonyms | A630031B11Rik, AU043390, DBA20, ribosomal protein S15A, S15a, uS8 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rps15a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ribosomal protein S8
- structural constituent of ribosome
- protein binding
Pathways
Biological processes and signaling networks where the Rps15a gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetes mellitus
- myelodysplastic syndrome
- metabolic syndrome X
- Diamond-Blackfan anemia type 20
- aortic valve calcification
role in cell
- expression in
- cell death
- proliferation
- cell cycle progression
- migration
- processing in
- invasion by
- translation in
- beta-catenin signaling in
- Wnt signaling in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pre-ribosome
- ribosome
- cytosol
- nucleoplasm
- nucleoli
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rps15a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cytoplasmic translation
- positive regulation of cell proliferation
- ribosomal small subunit biogenesis
- positive regulation of cell cycle
- response to virus
- translation
Cellular Component
Where in the cell the gene product is active
- small-subunit processome
- extracellular vesicular exosome
- cytosolic ribosome
- cytosolic small ribosomal subunit
- cytoplasm
- membrane
- cytosol
- synapse
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- structural constituent of ribosome