TIMM10 Gene Summary [Human]
The mitochondrial protein encoded by this gene belongs to a family of evolutionarily conserved proteins that are organized in heterooligomeric complexes in the mitochondrial intermembrane space. These proteins mediate the import and insertion of hydrophobic membrane proteins into the mitochondrial inner membrane, functioning as intermembrane space chaperones for the highly insoluble carrier proteins. [provided by RefSeq, Nov 2011]
Details
| Type | Protein Coding |
| Official Symbol | TIMM10 |
| Official Name | translocase of inner mitochondrial membrane 10 [Source:HGNC Symbol;Acc:HGNC:11814] |
| Ensembl ID | ENSG00000134809 |
| Bio databases IDs | |
| Aliases | translocase of inner mitochondrial membrane 10 |
| Synonyms | TIM10, TIM10A, Tim13, TIMM10A, Timm13a, translocase of inner mitochondrial membrane 10 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TIMM10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- zinc ion binding
- protein homodimerization
- Tim10/DDP family zinc finger
- protein binding
- chaperone binding
- transporter
Pathways
Biological processes and signaling networks where the TIMM10 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- inner membrane
- Mitochondria
- mitochondrial intermembrane space
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TIMM10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sensory perception of sound
- protein targeting to mitochondrion
- protein import into mitochondrial inner membrane
Cellular Component
Where in the cell the gene product is active
- mitochondrial inner membrane presequence translocase complex
- mitochondrial intermembrane space
- mitochondrion
- mitochondrial intermembrane space protein transporter complex
- mitochondrial inner membrane protein insertion complex
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- membrane insertase activity
- protein binding
- protein homodimerization activity
- chaperone binding