TDP2 Gene Summary [Human]
This gene encodes a member of a superfamily of divalent cation-dependent phosphodiesterases. The encoded protein associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor associated factors (TRAFs), and inhibits nuclear factor-kappa-B activation. This protein has sequence and structural similarities with APE1 endonuclease, which is involved in both DNA repair and the activation of transcription factors. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | TDP2 |
| Official Name | tyrosyl-DNA phosphodiesterase 2 [Source:HGNC Symbol;Acc:HGNC:17768] |
| Ensembl ID | ENSG00000111802 |
| Bio databases IDs | |
| Aliases | tyrosyl-DNA phosphodiesterase 2 |
| Synonyms | AD022, D13Ertd656e, dJ30M3.3, EAP2, EAPII, hTDP2, TTRAP, tyrosyl-DNA phosphodiesterase 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TDP2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- UBA domain-like superfamily
- transcription regulator
- UBA-like domain
- transcription co-repressor
- Endonuclease/Exonuclease/phosphatase family
- enzyme
- protein binding
- magnesium ion binding
- endonuclease
- single-stranded DNA binding
- Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
- manganese ion binding
- phosphoric diester hydrolase
Pathways
Biological processes and signaling networks where the TDP2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- lung cancer
- metabolic renal cell carcinoma
- renal cell cancer
- autosomal recessive spinocerebellar ataxia type 23
- endometrium tumor
- chronic obstructive pulmonary disease
- hereditary disorder
- weight loss
- renal cell carcinoma
role in cell
- apoptosis
- cell viability
- number
- migration
- accumulation in
- abnormal morphology
- molecular cleavage in
- transcription in
- accumulation
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- aggresome
- Nucleus
- nucleoplasm
- nuclear bodies
- PML nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TDP2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription, DNA-dependent
- cell surface receptor signaling pathway
- neuron development
- double-strand break repair
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- PML body
- cytoplasm
- nucleolus
- aggresome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- protein binding
- 5'-tyrosyl-DNA phosphodiesterase activity
- transcription corepressor activity
- nuclease activity
- manganese ion binding
- single-stranded DNA binding