PKIB Gene Summary [Human]
This gene encodes a member of the cAMP-dependent protein kinase inhibitor family. The encoded protein may play a role in the protein kinase A (PKA) pathway by interacting with the catalytic subunit of PKA, and overexpression of this gene may play a role in prostate cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Details
| Type | Protein Coding |
| Official Symbol | PKIB |
| Official Name | cAMP-dependent protein kinase inhibitor beta [Source:HGNC Symbol;Acc:HGNC:9018] |
| Ensembl ID | ENSG00000135549 |
| Bio databases IDs | |
| Aliases | cAMP-dependent protein kinase inhibitor beta |
| Synonyms | cAMP-Dependent Protein Kinase Inhibitor, cAMP-Dependent Protein Kinase Inhibitor 2, cAMP-dependent protein kinase inhibitor beta, cAMP-dependent protein kinase inhibitor β, LOC100362071, Pkibeta, PKINH, PRKACN2, protein kinase inhibitor beta, cAMP dependent, testis specific, protein kinase inhibitor β, cAMP dependent, testis specific, RATPKINH |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PKIB often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cAMP-dependent protein kinase inhibitor
- cAMP-dependent protein kinase inhibitor activity
- protein binding
Pathways
Biological processes and signaling networks where the PKIB gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PKIB gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of cAMP-dependent protein kinase activity
- positive regulation of telomerase activity
- positive regulation of telomere maintenance via telomerase
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- cAMP-dependent protein kinase inhibitor activity