NMBR Gene Summary [Human]
This gene encodes a 7-transmembrane G protein-coupled receptor that binds neuromedin B, which is a growth factor and mitogen for gastrointestinal epithelial tissue and for normal and neoplastic lung. This receptor may play a role in smooth muscle contraction, neuronal responses, and the regulation of cell growth. Antagonists of this receptor have a potential therapeutic use in inhibiting tumor cell growth. Polymorphisms in this gene may be associated with a susceptibility for schizophrenia. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2016]
Details
| Type | Processed Transcript |
| Official Symbol | NMBR |
| Official Name | neuromedin B receptor [Source:HGNC Symbol;Acc:HGNC:7843] |
| Ensembl ID | ENSG00000135577 |
| Bio databases IDs | |
| Aliases | neuromedin B receptor, bombesin receptor 1 |
| Synonyms | BB1, BB182387, BB1R, Bb1 Receptor, BRS1, LOC100361806, LOC102552086, LOC681272, neuromedin B receptor |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NMBR often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- extracellular domain
- Cholecystokinin A receptor, N-terminal
- neuropeptide receptor
- transmembrane domain
- intracellular domain
- 7 transmembrane receptor (rhodopsin family)
- seven-transmembrane G protein-coupled receptor superfamily
- bombesin receptor
Pathways
Biological processes and signaling networks where the NMBR gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pruritus
- sneeze
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NMBR gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of interleukin-6 production
- bombesin receptor signaling pathway
- positive regulation of interferon-alpha production
- neuropeptide signaling pathway
- G-protein coupled receptor signaling pathway
- phospholipase C-activating G-protein coupled receptor signaling pathway
- positive regulation of osteoclast proliferation
Cellular Component
Where in the cell the gene product is active
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- bombesin receptor activity
- neuropeptide receptor activity