MICAL1 Gene Summary [Human]
This gene encodes an enzyme that oxidizes methionine residues on actin, thereby promoting depolymerization of actin filaments. This protein interacts with and regulates signalling by NEDD9/CAS-L (neural precursor cell expressed, developmentally down-regulated 9). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
Details
| Type | Retained Intron |
| Official Symbol | MICAL1 |
| Official Name | microtubule associated monooxygenase, calponin and LIM domain containing 1 [Source:HGNC Symbol;Acc:HGNC:20619] |
| Ensembl ID | ENSG00000135596 |
| Bio databases IDs | |
| Aliases | microtubule associated monooxygenase, calponin and LIM domain containing 1, protein-methionine sulfoxide oxidase MICAL1 |
| Synonyms | MICAL, microtubule associated monooxygenase, calponin and LIM domain containing 1, NICAL |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MICAL1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase binding
- Calponin homology domain
- Sperm tail
- LIM is a small protein-protein interaction domain, containing two zinc fingers
- enzyme binding
- leucine zipper domain
- enzyme
- protein binding
- proline rich domain
- SH3-domain binding
- FAD binding
- actin binding
- NADPH oxidase
- Bivalent Mical/EHBP Rab binding domain
- NAD(P)-binding Rossmann-like domain
- calponin homology (CH) domain superfamily
- monooxygenase
- cysteine-histidine rich domain
- NADH2 or NADPH2 1 atom incorporation:oxygen oxidoreductase
Pathways
Biological processes and signaling networks where the MICAL1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- pancreatic cancer
- major depression
- metastasis
- advanced cancer
- autosomal dominant partial epilepsy with auditory features
role in cell
- tumorigenicity
- migration
- growth
- activation in
- apoptosis
- expression in
- phosphorylation in
- abnormal morphology
- invasion by
- depolymerization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cilia
- perinuclear region
- filamentous network
- Plasma Membrane
- basal bodies
- actin filaments
- midbody
- cytoplasmic bridges
- cytosol
- endosomal membrane
- nucleoplasm
- membrane processes
- axon terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MICAL1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sulfur oxidation
- cytoskeleton organization
- signal transduction
- negative regulation of apoptotic process
- actin filament depolymerization
- negative regulation of protein phosphorylation
- actin filament bundle assembly
Cellular Component
Where in the cell the gene product is active
- intercellular bridge
- cytoplasm
- actin cytoskeleton
- cytosol
- intermediate filament
- endosome membrane
- midbody
- actin filament
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- FAD binding
- actin filament binding
- protein kinase binding
- protein binding
- actin binding
- metal ion binding
- NAD(P)H oxidase activity
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen
- small GTPase binding
- SH3 domain binding
- monooxygenase activity