STK38L Gene Summary [Human]
Enables ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in intracellular signal transduction. Acts upstream of or within protein phosphorylation. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | STK38L |
| Official Name | serine/threonine kinase 38 like [Source:HGNC Symbol;Acc:HGNC:17848] |
| Ensembl ID | ENSG00000211455 |
| Bio databases IDs | |
| Aliases | serine/threonine kinase 38 like, nuclear Dbf2-related 2 |
| Synonyms | 4930473A22Rik, LOC686663, NDR2, NDR2 protein kinase, Ndr54, RGD1564793, serine/threonine kinase 38 like |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human STK38L often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- Protein kinase C terminal domain
- Protein tyrosine and serine/threonine kinase
- ATP binding
- protein binding
- magnesium ion binding
- Protein kinase domain
- SMA domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- Protein Kinases, catalytic domain
- Extension to Ser/Thr-type protein kinases
- Tyrosine kinase, catalytic domain
- Mob-binding domain found in the NDR/LATS family serine/threonine protein kinases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- dementia
- headache
- glioma formation
- colon cancer
- glioma
- idiopathic scoliosis
role in cell
- growth
- G1 phase
- expression in
- outgrowth
- proliferation
- autophagy by
- phosphorylation in
- abnormal morphology
- invasion
- growth in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- perinuclear region
- cellular membrane
- actin cytoskeleton
- cell-cell contacts
- cytosol
- dendritic spines
- growth cone
- neurites
- recycling endosomes
- early endosomes
- perikaryon
- axons
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human STK38L gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of autophagy
- protein phosphorylation
- peptidyl-serine phosphorylation
- intracellular signal transduction
- regulation of cellular component organization
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- membrane
- actin cytoskeleton
- cytosol
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- ATP binding
- protein binding
- actin binding
- protein serine/threonine kinase activity