STK38 Gene Summary [Human]
This gene encodes a member of the AGC serine/threonine kinase family of proteins. The kinase activity of this protein is regulated by autophosphorylation and phosphorylation by other upstream kinases. This protein has been shown to function in the cell cycle and apoptosis. This protein has also been found to regulate the protein stability and transcriptional activity of the MYC oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
Details
| Type | Protein Coding |
| Official Symbol | STK38 |
| Official Name | serine/threonine kinase 38 [Source:HGNC Symbol;Acc:HGNC:17847] |
| Ensembl ID | ENSG00000112079 |
| Bio databases IDs | |
| Aliases | serine/threonine kinase 38, nuclear Dbf2-related 1 |
| Synonyms | 5830476G13Rik, 9530097A09Rik, NDR, NDR1, serine/threonine kinase 38 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human STK38 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase binding
- regulatory domain
- Protein kinase C terminal domain
- Protein tyrosine and serine/threonine kinase
- protein binding activity, bridging
- ATP binding
- protein binding
- magnesium ion binding
- Protein kinase domain
- SMA domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- Extension to Ser/Thr-type protein kinases
- Tyrosine kinase, catalytic domain
- Mob-binding domain found in the NDR/LATS family serine/threonine protein kinases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- cervical cancer
- ulcerative colitis
- epithelial uterine cancer
- thrombocytopenia
- TNBS-induced colitis
- cervical small cell carcinoma
- extrapulmonary small cell cancer
- infection by bacteria
role in cell
- proliferation
- expression in
- apoptosis
- phosphorylation in
- accumulation in
- degradation in
- replication in
- formation
- formation in
- turnover in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- glutaminergic synapse
- Cytoplasm
- perinuclear region
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human STK38 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA damage checkpoint
- protein modification process
- negative regulation of MAP kinase activity
- response to DNA damage stimulus
- chromatin organization
- protein phosphorylation
- peptidyl-serine phosphorylation
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- nucleus
- site of double-strand break
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- ATP binding
- protein binding
- cadherin binding
- protein serine/threonine kinase activity
- mitogen-activated protein kinase kinase kinase binding