DYNC1LI2 Gene Summary [Human]
Cytoplasmic dynein is a microtubule-associated motor protein (Hughes et al., 1995 [PubMed 7738094]). See DYNC1H1 (MIM 600112) for general information about dyneins.[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | DYNC1LI2 |
| Official Name | dynein cytoplasmic 1 light intermediate chain 2 [Source:HGNC Symbol;Acc:HGNC:2966] |
| Ensembl ID | ENSG00000135720 |
| Bio databases IDs | |
| Aliases | dynein cytoplasmic 1 light intermediate chain 2 |
| Synonyms | AA409702, C920003I06, Dlic2, DNCLI2, Dnclic2, dynein cytoplasmic 1 light intermediate chain 2, dynein, cytoplasmic 1 light intermediate chain 2, LIC2, LIC53/55 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DYNC1LI2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Dynein light intermediate chain (DLIC)
- protein binding
- identical protein binding
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the DYNC1LI2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
role in cell
- cohesion
- formation
- dispersal
- organization
- cohesion in
- formation in
- stability
- localization
- dispersal in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- centrosome
- cytosol
- Golgi membrane
- late endosomes
- kinetochores
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DYNC1LI2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- centrosome localization
- microtubule cytoskeleton organization
- microtubule-based movement
Cellular Component
Where in the cell the gene product is active
- cytoplasmic dynein complex
- centrosome
- membrane
- late endosome
- dynein complex
- cytosol
- kinetochore
- microtubule
Molecular Function
What the gene product does at the molecular level
- ATP binding
- identical protein binding
- dynein heavy chain binding