HTR6 Gene Summary [Human]
This gene encodes a protein that belongs to the seven-transmembrane G protein-coupled receptor family of proteins. The encoded protein couples with the Gs alpha subunit and stimulates adenylate cyclase to activate the cyclic AMP-dependent signaling pathway. This receptor is thought to regulate cholinergic neuronal transmission in the brain. Several antidepressants and antipsychotic drugs have a high affinity for this receptor. [provided by RefSeq, Aug 2013]
Details
| Type | Protein Coding |
| Official Symbol | HTR6 |
| Official Name | 5-hydroxytryptamine receptor 6 [Source:HGNC Symbol;Acc:HGNC:5301] |
| Ensembl ID | ENSG00000158748 |
| Bio databases IDs | |
| Aliases | 5-hydroxytryptamine receptor 6 |
| Synonyms | 5-HT6, 5-HT6R, 5-HT6 receptor, 5HTR6, 5-hydroxytryptamine receptor 6, 5-hydroxytryptamine (serotonin) receptor 6 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human HTR6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- histamine receptor
- serotonin receptor
- transmembrane domain
- extracellular loop
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
- transmembrane receptor
Pathways
Biological processes and signaling networks where the HTR6 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- post-traumatic stress disorder
- headache
- alcoholism
- schizophrenia
- vomiting
- schizophrenia spectrum disorder
- chemotherapy sickness
- schizoaffective disorder
- bipolar disorder
- undernutrition
role in cell
- expression in
- activation in
- migration
- generation in
- elongation
- branching
- branching in
- elongation in
- outgrowth in
- ciliogenesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- cilia
- intracellular membranes
- cellular membrane
- perikaryon
- dendrites
- axon branches
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human HTR6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
- synaptic transmission
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway
- positive regulation of TOR signaling cascade
- cerebral cortex cell migration
Cellular Component
Where in the cell the gene product is active
- dendrite
- cilium
- synapse
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- histamine receptor activity
- neurotransmitter receptor activity
- serotonin receptor activity