NUDT15 Gene Summary [Human]
This gene encodes an enzyme that belongs to the Nudix hydrolase superfamily. Members of this superfamily catalyze the hydrolysis of nucleoside diphosphates, including substrates like 8-oxo-dGTP, which are a result of oxidative damage, and can induce base mispairing during DNA replication, causing transversions. The encoded enzyme is a negative regulator of thiopurine activation and toxicity. Mutations in this gene result in poor metabolism of thiopurines, and are associated with thiopurine-induced early leukopenia. Multiple pseudogenes of this gene have been identified. [provided by RefSeq, Apr 2016]
Details
| Type | Protein Coding |
| Official Symbol | NUDT15 |
| Official Name | nudix hydrolase 15 [Source:HGNC Symbol;Acc:HGNC:23063] |
| Ensembl ID | ENSG00000136159 |
| Bio databases IDs | |
| Aliases | nudix hydrolase 15 |
| Synonyms | 6530403O17, A730068G11RIK, LOC100047504, MTH2, nudix hydrolase 15, NUDT15D |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NUDT15 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- nucleoside-diphosphatase
- NUDIX domain
- 7,8-dihydro-8-oxoguanine-triphosphatase
- nucleoside-triphosphate diphosphatase
- phosphatase
- protein binding
- NUDIX hydrolase superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NUDT15 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of proteasomal protein catabolic process
- nucleobase-containing small molecule metabolic process
- DNA protection
- purine nucleotide catabolic process
- xenobiotic catabolic process
- response to reactive oxygen species
- mitotic cell cycle
- dGTP catabolic process
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
- nucleoside-triphosphate diphosphatase activity
- 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity