Nudt15 Gene Summary [Mouse]
Enables 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity. Acts upstream of or within purine deoxyribonucleoside triphosphate catabolic process and response to reactive oxygen species. Predicted to be active in cytosol. Used to study leukopenia; neutropenia; and pancytopenia. Human ortholog(s) of this gene implicated in poor metabolism of thiopurines 2. Orthologous to human NUDT15 (nudix hydrolase 15). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nudt15 |
| Official Name | nudix (nucleoside diphosphate linked moiety X)-type motif 15 [Source:MGI Symbol;Acc:MGI:2443366] |
| Ensembl ID | ENSMUSG00000033405 |
| Bio databases IDs | |
| Aliases | nudix (nucleoside diphosphate linked moiety X)-type motif 15 |
| Synonyms | 6530403O17, A730068G11RIK, LOC100047504, MTH2, nudix hydrolase 15, NUDT15D |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nudt15 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- nucleoside-diphosphatase
- NUDIX domain
- 7,8-dihydro-8-oxoguanine-triphosphatase
- nucleoside-triphosphate diphosphatase
- phosphatase
- protein binding
- NUDIX hydrolase superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nudt15 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of proteasomal protein catabolic process
- nucleobase-containing small molecule metabolic process
- DNA protection
- purine nucleotide catabolic process
- xenobiotic catabolic process
- response to reactive oxygen species
- mitotic cell cycle
- dGTP catabolic process
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
- nucleoside-triphosphate diphosphatase activity
- 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity