RPS6KC1 Gene Summary [Human]
Sphingosine kinase catalyzes the formation of sphingosine 1 phosphate, a lipid cellular messenger. The protein encoded by this gene can bind to sphingosine kinase and to phosphatidylinositol 3-phosphate, suggesting a role in sphingosine 1 phophate signaling. The encoded protein can also bind to peroxiredoxin-3 and may help transport it to mitochondria. [provided by RefSeq, Mar 2017]
Details
| Type | Protein Coding |
| Official Symbol | RPS6KC1 |
| Official Name | ribosomal protein S6 kinase C1 [Source:HGNC Symbol;Acc:HGNC:10439] |
| Ensembl ID | ENSG00000136643 |
| Bio databases IDs | |
| Aliases | ribosomal protein S6 kinase C1 |
| Synonyms | AA682037, B130003F20RIK, C80612, humS6PKh1, LOC105372910, LOC105372912, ribosomal protein S6 kinase C1, ribosomal protein S6 kinase polypeptide 1, RPK118, RSKL1, S6K-delta-1, S6K-δ-1, S6PKh1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RPS6KC1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Microtubule Interacting and Trafficking molecule domain
- MIT (microtubule interacting and transport) domain
- protein serine/threonine kinase
- MIT
- The Phox Homology domain, a phosphoinositide binding module
- protein binding
- pseudo kinase domain
- PX domain
Pathways
Biological processes and signaling networks where the RPS6KC1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endosomes
- lysosome
- cytosol
- early endosomes
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RPS6KC1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
Cellular Component
Where in the cell the gene product is active
- early endosome
- endosome
- membrane
- lysosome
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- phosphatidylinositol binding
- protein serine/threonine kinase activity