PSMD2 Gene Summary [Human]
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. In addition to participation in proteasome function, this subunit may also participate in the TNF signalling pathway since it interacts with the tumor necrosis factor type 1 receptor. A pseudogene has been identified on chromosome 1. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]
Details
| Type | Protein Coding |
| Official Symbol | PSMD2 |
| Official Name | proteasome 26S subunit, non-ATPase 2 [Source:HGNC Symbol;Acc:HGNC:9559] |
| Ensembl ID | ENSG00000175166 |
| Bio databases IDs | |
| Aliases | proteasome 26S subunit, non-ATPase 2, proteasome 26S subunit ubiquitin receptor, non-ATPase 2 |
| Synonyms | 9430095H01Rik, P97, proteasome 26S subunit ubiquitin receptor, non-ATPase 2, proteasome (prosome, macropain) 26S subunit, non-ATPase, 2, RPN1, S2, TEG-190, Tex190, TRAP2, TUMOR NECROSIS FACTOR type 1 receptor-ASSOCIATED protein 2, tumour NECROSIS FACTOR type 1 receptor-ASSOCIATED protein 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PSMD2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 26S proteasome non-ATPase regulatory subunit RPN1 C-terminal
- RPN1 N-terminal domain
- KEKE domain
- coiled-coil domain
- protein binding
- Proteasome/cyclosome repeat
Pathways
Biological processes and signaling networks where the PSMD2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- precursor B-cell acute lymphoblastic leukemia
- plasma cell myeloma
- progressive multiple myeloma
- lymphoplasmacytic lymphoma
- relapsed multiple myeloma
- immune thrombocytopenia
- refractory multiple myeloma
- systemic light chain amyloidosis
- B-cell acute lymphoblastic lymphoma
- idiopathic thrombocytopenic purpura
role in cell
- proliferation
- cell death
- degradation in
- replication in
- growth
- fragmentation
- fragmentation in
- formation
- activation in
- consumption in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent resistant lipid raft fraction
- ciliary transition zone
- secretory granule lumen
- ficolin-1-rich granule lumen
- Extracellular Space
- basal bodies
- cytosol
- endoplasmic reticulum membrane
- nucleoplasm
- clastosomes
- chromatin
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PSMD2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
- regulation of protein catabolic process
Cellular Component
Where in the cell the gene product is active
- proteasome regulatory particle, base subcomplex
- proteasome complex
- proteasome accessory complex
- extracellular region
- nucleoplasm
- nucleus
- extracellular vesicular exosome
- proteasome regulatory particle
- membrane
- cytosol
- secretory granule lumen
- proteasome storage granule
Molecular Function
What the gene product does at the molecular level
- protein binding
- enzyme regulator activity