GOLGA1 Gene Summary [Human]

The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodes one of the golgins, a family of proteins localized to the Golgi. This encoded protein is associated with Sjogren's syndrome. [provided by RefSeq, Feb 2010]

Details

Type
Protein Coding
Official Symbol
GOLGA1
Official Name
golgin A1 [Source:HGNC Symbol;Acc:HGNC:4424]
Ensembl ID
ENSG00000136935
Bio databases IDs NCBI: 2800 Ensembl: ENSG00000136935
Aliases golgin A1
Synonyms 0710001G09Rik, 2210418B03Rik, awag, Golgi97, golgin-97, golgin A1
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GOLGA1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
  • GRIP domain
  • protein binding
  • Calcium binding and coiled-coil domain (CALCOCO1) like

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • atopic dermatitis
  • preeclampsia
regulated by

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • perinuclear region
  • cellular membrane
  • Golgi Apparatus
  • cytosol
  • medial face of the Golgi apparatus
  • trans face of the Golgi apparatus
  • Golgi stacks
  • trans Golgi network
  • cis Golgi cisternae
  • cytosolic fraction

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human GOLGA1 gene, providing context for its role in the cell.

Cellular Component

Where in the cell the gene product is active
  • trans-Golgi network
  • perinuclear region of cytoplasm
  • acrosomal vesicle
  • cytosol
  • Golgi apparatus
  • Golgi membrane

Molecular Function

What the gene product does at the molecular level
  • protein binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.