ARFGAP2 Gene Summary [Human]
Predicted to enable GTPase activator activity. Predicted to be involved in COPI coating of Golgi vesicle. Located in Golgi apparatus; cytosol; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | ARFGAP2 |
| Official Name | ADP ribosylation factor GTPase activating protein 2 [Source:HGNC Symbol;Acc:HGNC:13504] |
| Ensembl ID | ENSG00000149182 |
| Bio databases IDs | |
| Aliases | ADP ribosylation factor GTPase activating protein 2 |
| Synonyms | 2310032E02Rik, ARF GTPase activating protein 2, IRZ, NBLA10535, ZFP289, ZNF289 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ARFGAP2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Putative GTP-ase activating proteins for the small GTPase, ARF
- GTPase-activating protein (GAP) for the ADP ribosylation factors (ARFs)
- Putative GTPase activating protein for Arf
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Plasma Membrane
- Golgi Apparatus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ARFGAP2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein transport
- COPI coating of Golgi vesicle
Cellular Component
Where in the cell the gene product is active
- cytosol
- Golgi apparatus
- Golgi membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- GTPase activator activity