ARL1 Gene Summary [Human]
The protein encoded by this gene belongs to the ARL (ADP-ribosylation factor-like) family of proteins, which are structurally related to ADP-ribosylation factors (ARFs). ARFs, described as activators of cholera toxin (CT) ADP-ribosyltransferase activity, regulate intracellular vesicular membrane trafficking, and stimulate a phospholipase D (PLD) isoform. Although, ARL proteins were initially thought not to activate CT or PLD, later work showed that they are weak stimulators of PLD and CT in a phospholipid dependent manner. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]
Details
| Type | Protein Coding |
| Official Symbol | ARL1 |
| Official Name | ADP ribosylation factor like GTPase 1 [Source:HGNC Symbol;Acc:HGNC:692] |
| Ensembl ID | ENSG00000120805 |
| Bio databases IDs | |
| Aliases | ADP ribosylation factor like GTPase 1 |
| Synonyms | 2310008D22Rik, ADP-ribosylation factor-like 1, ARFL1, ARF like GTPase 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ARL1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GTP binding domain-switch II region
- Ras family
- 50S ribosome-binding GTPase
- GTPase
- protein domain specific binding
- enzyme
- protein binding
- enzyme activator activity
- phospholipase activator
- GTP binding
- Sar1p-like members of the Ras-family of small GTPases
- ADP-ribosylation factor family
- small GTP-binding protein domain
- Rab subfamily of small GTPases
- Ras of Complex, Roc, domain of DAPkinase
- ADP-ribosylation factor
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetic nephropathy
role in cell
- growth
- morphology
- organization
- transport
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi Apparatus
- cytosol
- trans Golgi network
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ARL1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- vesicle-mediated transport
- protein localization in Golgi apparatus
- Golgi organization
- retrograde transport, endosome to Golgi
- intracellular protein transport
- toxin metabolic process
Cellular Component
Where in the cell the gene product is active
- trans-Golgi network
- cytoplasm
- cytosol
- Golgi membrane
- Golgi apparatus
- trans-Golgi network membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein domain specific binding
- protein binding
- metal ion binding
- GTPase activity
- enzyme activator activity