TRIM26 Gene Summary [Human]
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. Although the function of the protein is unknown, the RING domain suggests that the protein may have DNA-binding activity. The gene localizes to the major histocompatibility complex (MHC) class I region on chromosome 6. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2011]
Details
| Type | Processed Transcript |
| Official Symbol | TRIM26 |
| Official Name | tripartite motif containing 26 [Source:HGNC Symbol;Acc:HGNC:12962] |
| Ensembl ID | ENSG00000137313 |
| Bio databases IDs | |
| Aliases | tripartite motif containing 26 |
| Synonyms | Acid finger, AFP, RNF95, tripartite motif-containing 26, Zfp173, Zfp1736, ZNF173 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TRIM26 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SPRY domain
- ubiquitin protein ligase activity
- zinc finger of C3HC4-type, RING
- enzyme
- Ring finger domain
- protein binding
- associated with SPRY domains
- B-box-type zinc finger superfamily
- RING-type zinc-finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- B-box zinc finger
- SPRY-associated domain
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- neoplasia
- non-small cell lung cancer
- lung squamous cell carcinoma
- squamous cell lung cancer
- organismal death
- Takayasu arteritis
- chronic obstructive pulmonary disease
- hypothyroidism
- bipolar disorder
role in cell
- production in
- binding in
- proliferation
- expression in
- migration
- colony formation by
- infiltration by
- upregulation in
- K48 polyubiquitination in
- degradation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TRIM26 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein K11-linked ubiquitination
- proteasomal ubiquitin-dependent protein catabolic process
- negative regulation of viral entry into host cell
- innate immune response
- positive regulation of sequence-specific DNA binding transcription factor activity
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- DNA binding
- zinc ion binding
- protein binding
- metal ion binding