DDR1 Gene Summary [Human]
Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain, and that are activated by various types of collagen. Expression of this protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]
Details
| Type | Processed Transcript |
| Official Symbol | DDR1 |
| Official Name | discoidin domain receptor tyrosine kinase 1 [Source:HGNC Symbol;Acc:HGNC:2730] |
| Ensembl ID | ENSG00000137332 |
| Bio databases IDs | |
| Aliases | discoidin domain receptor tyrosine kinase 1 |
| Synonyms | 6030432F18, CAK, CD167, CD167a, CD167a antigen, DDR, discoidin domain receptor family, member 1, discoidin domain receptor tyrosine kinase 1, Drd1, EDDR1, HGK2, MCK10, NEP, NTRK4, PTK3, PTK3A, PTK3D, RTK6, TRKE, Tyrosine kinase DDR |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DDR1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- Protein kinase (unclassified specificity)
- Coagulation factor 5/8 C-terminal domain, discoidin domain
- Protein tyrosine and serine/threonine kinase
- catalytic domain
- protein binding
- protein-tyrosine kinase
- Protein kinase domain
- collagen receptor
- kinase
- Serine/Threonine protein kinases, catalytic domain
- Protein Kinases, catalytic domain
- transmembrane receptor protein tyrosine kinase
- stalk region
- transmembrane domain
- collagen binding
- F5/8 type C domain
- intracellular domain
- membrane-proximal domain
- Tyrosine kinase, catalytic domain
- transmembrane receptor
- FA58C
Pathways
Biological processes and signaling networks where the DDR1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- metastasis
- neoplasia
- fibrosis
- schizophrenia
- epithelial cancer
- breast cancer
- invasive breast cancer
- hypereosinophilic syndrome
- chronic myeloid leukemia
role in cell
- differentiation
- expression in
- proliferation
- apoptosis
- upregulation in
- growth
- cell viability
- phosphorylation in
- activation in
- motility
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- basolateral membrane
- brush border
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DDR1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell proliferation
- wound healing, spreading of cells
- multicellular organismal development
- negative regulation of cell proliferation
- peptidyl-tyrosine autophosphorylation
- protein autophosphorylation
- transmembrane receptor protein tyrosine kinase signaling pathway
- lactation
- cell adhesion
- collagen-activated tyrosine kinase receptor signaling pathway
- branching involved in mammary gland duct morphogenesis
- smooth muscle cell-matrix adhesion
- embryo implantation
- smooth muscle cell migration
- regulation of cell-matrix adhesion
- mammary gland alveolus development
- regulation of cell growth
- ear development
- positive regulation of ERK1 and ERK2 cascade
- regulation of extracellular matrix disassembly
- positive regulation of neuron projection development
- positive regulation of kinase activity
- positive regulation of protein kinase B signaling cascade
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- receptor complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- collagen binding
- transmembrane receptor protein tyrosine kinase activity
- metal ion binding
- protein tyrosine kinase collagen receptor activity