TRIM15 Gene Summary [Human]
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to the cytoplasm. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | TRIM15 |
| Official Name | tripartite motif containing 15 [Source:HGNC Symbol;Acc:HGNC:16284] |
| Ensembl ID | ENSG00000137384 |
| Bio databases IDs | |
| Aliases | tripartite motif containing 15 |
| Synonyms | 1810012B10Rik, RNF93, tripartite motif-containing 15, ZNF178, ZNFB7 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TRIM15 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription co-activator
- SPRY domain
- zinc finger of C3HC4-type, RING
- enzyme
- protein binding
- associated with SPRY domains
- B-box-type zinc finger superfamily
- RING-type zinc-finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- B-box zinc finger
- SPRY-associated domain
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- tonsillitis
- neoplasia
- chronic obstructive pulmonary disease
- ulcerative colitis
- insomnia
- dry eye syndrome
role in cell
- proliferation
- growth
- activation in
- commitment
- interaction in
- K63 polyubiquitination in
- innate immune response in
- modification in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TRIM15 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription, DNA-dependent
- innate immune response
- positive regulation of type I interferon production
- positive regulation of RIG-I signaling pathway
- positive regulation of sequence-specific DNA binding transcription factor activity
- positive regulation of NF-kappaB transcription factor activity
- mesodermal cell fate determination
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- focal adhesion
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- transcription coactivator activity