BRDT Gene Summary [Human]
BRDT is similar to the RING3 protein family. It possesses 2 bromodomain motifs and a PEST sequence (a cluster of proline, glutamic acid, serine, and threonine residues), characteristic of proteins that undergo rapid intracellular degradation. The bromodomain is found in proteins that regulate transcription. Several transcript variants encoding multiple isoforms have been found for this gene. [provided by RefSeq, Jun 2011]
Details
| Type | Protein Coding |
| Official Symbol | BRDT |
| Official Name | bromodomain testis associated [Source:HGNC Symbol;Acc:HGNC:1105] |
| Ensembl ID | ENSG00000137948 |
| Bio databases IDs | |
| Aliases | bromodomain testis associated, cancer/testis antigen 9 |
| Synonyms | 7420412D09Rik, BRD6, bromodomain testis associated, bromodomain, testis-specific, CT9, FSRG3, SPGF21 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human BRDT often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- histone binding
- protein serine/threonine kinase
- transcription co-activator
- protein binding activity, bridging
- protein binding
- Bromodomain extra-terminal - transcription regulation
- Bromodomain
- C-terminal domain of bromodomain protein 4
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- spermatogenic failure 21
- premature ovarian failure
- productive infection by HIV-1
role in cell
- remodeling
- reorganization
- elongation
- reorganization in
- meiosis
- condensation
- meiosis I
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human BRDT gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA splicing
- chromatin remodeling
- positive regulation of transcription, DNA-dependent
- male meiosis
- positive regulation of gene expression
- regulation of RNA splicing
- male meiosis I
- regulation of transcription, DNA-dependent
- sperm chromatin condensation
- mRNA processing
Cellular Component
Where in the cell the gene product is active
- nucleus
Molecular Function
What the gene product does at the molecular level
- transcription coactivator activity
- histone binding
- histone acetyl-lysine binding