Brdt Gene Summary [Mouse]
The protein encoded by this gene belongs to the BET protein family. BET proteins have two N-terminal bromodomains and one C-terminal extraterminal domain (ET domain). BET proteins regulate chromatin reorganization via binding to acetylated histones. This gene is thought to play a role in the transcriptional regulation of spermatogenesis. Although referred to as testis-specific bromodomain (Brdt) protein, RT-PCR indicates that this gene is expressed in both mouse oocytes and testes. Alternative splicing results in multiple transcript variants encoding different proteins. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | Brdt |
| Official Name | bromodomain, testis-specific [Source:MGI Symbol;Acc:MGI:1891374] |
| Ensembl ID | ENSMUSG00000029279 |
| Bio databases IDs | |
| Aliases | bromodomain, testis-specific |
| Synonyms | 7420412D09Rik, BRD6, bromodomain testis associated, bromodomain, testis-specific, CT9, FSRG3, SPGF21 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Brdt often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- histone binding
- protein serine/threonine kinase
- transcription co-activator
- protein binding activity, bridging
- protein binding
- Bromodomain extra-terminal - transcription regulation
- Bromodomain
- C-terminal domain of bromodomain protein 4
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- spermatogenic failure 21
- premature ovarian failure
- productive infection by HIV-1
role in cell
- remodeling
- reorganization
- elongation
- reorganization in
- meiosis
- condensation
- meiosis I
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Brdt gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA splicing
- chromatin remodeling
- positive regulation of transcription, DNA-dependent
- male meiosis
- positive regulation of gene expression
- regulation of RNA splicing
- male meiosis I
- regulation of transcription, DNA-dependent
- sperm chromatin condensation
- mRNA processing
Cellular Component
Where in the cell the gene product is active
- nucleus
Molecular Function
What the gene product does at the molecular level
- transcription coactivator activity
- histone binding
- histone acetyl-lysine binding