ARHGAP29 Gene Summary [Human]
Rap1 is a small GTPase that, through effectors, regulates Rho GTPase signaling. These effectors- Rasip1, Radil, and the protein encoded by this gene- translocate to the cell membrane, where they form a multiprotein complex. This complex is necessary for Rap1-induced inhibition of Rho signaling. Defects in this gene may be a cause of nonsyndromic cleft lip with or without cleft palate. [provided by RefSeq, Jun 2016]
Details
| Type | Retained Intron |
| Official Symbol | ARHGAP29 |
| Official Name | Rho GTPase activating protein 29 [Source:HGNC Symbol;Acc:HGNC:30207] |
| Ensembl ID | ENSG00000137962 |
| Bio databases IDs | |
| Aliases | Rho GTPase activating protein 29 |
| Synonyms | 6720461J18Rik, A830014I19, B130017I01Rik, C76601, LOC103695137, PARG1, RGD1306185, Rho GTPase activating protein 29 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ARHGAP29 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RhoGAP domain
- Ezrin/radixin/moesin, alpha-helical domain
- protein kinase C conserved region 1 (C1 domain) superfamily
- GTPase activator
- protein binding
- GTPase Activating Protein domain
- Bin/Amphiphysin/Rvs domain
- GTPase-activator protein for Rho-like GTPases
- RhoGAP
- PDZ-domain binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ARHGAP29 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of small GTPase mediated signal transduction
- Rho protein signal transduction
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- macromolecular complex
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- GTPase activator activity
- PDZ domain binding