Arhgap29 Gene Summary [Rat]
Predicted to enable ATP hydrolysis activity; glycerophospholipid flippase activity; and retinal binding activity. Predicted to be involved in phospholipid translocation and retinal metabolic process. Predicted to act upstream of or within phospholipid transfer to membrane; photoreceptor cell maintenance; and visual perception. Predicted to be located in cytoplasmic vesicle; endoplasmic reticulum; and photoreceptor outer segment. Human ortholog(s) of this gene implicated in fundus dystrophy and retinal degeneration (multiple). Orthologous to human ABCA4 (ATP binding cassette subfamily A member 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Arhgap29 |
| Official Name | Rho GTPase activating protein 29 [Source:RGD Symbol;Acc:1306185] |
| Ensembl ID | ENSRNOG00000012563 |
| Bio databases IDs | |
| Aliases | Rho GTPase activating protein 29 |
| Synonyms | 6720461J18Rik, A830014I19, B130017I01Rik, C76601, LOC103695137, PARG1, RGD1306185, Rho GTPase activating protein 29 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Arhgap29 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RhoGAP domain
- Ezrin/radixin/moesin, alpha-helical domain
- protein kinase C conserved region 1 (C1 domain) superfamily
- GTPase activator
- protein binding
- GTPase Activating Protein domain
- Bin/Amphiphysin/Rvs domain
- GTPase-activator protein for Rho-like GTPases
- RhoGAP
- PDZ-domain binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- nonsyndromic cleft lip with or without cleft palate
- hepatitis
- prostate cancer
role in cell
- docetaxel resistance
- glycolysis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Arhgap29 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of small GTPase mediated signal transduction
- Rho protein signal transduction
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- macromolecular complex
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- GTPase activator activity
- PDZ domain binding