Arhgap29 Gene Summary [Mouse]
Predicted to enable GTPase activator activity and PDZ domain binding activity. Predicted to be involved in negative regulation of small GTPase mediated signal transduction. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm. Is expressed in several structures, including 1st branchial arch; alimentary system epithelium; facial prominence; meninges; and skin. Orthologous to human ARHGAP29 (Rho GTPase activating protein 29). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Arhgap29 |
| Official Name | Rho GTPase activating protein 29 [Source:MGI Symbol;Acc:MGI:2443818] |
| Ensembl ID | ENSMUSG00000039831 |
| Bio databases IDs | |
| Aliases | Rho GTPase activating protein 29 |
| Synonyms | 6720461J18Rik, A830014I19, B130017I01Rik, C76601, LOC103695137, PARG1, RGD1306185, Rho GTPase activating protein 29 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Arhgap29 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RhoGAP domain
- Ezrin/radixin/moesin, alpha-helical domain
- protein kinase C conserved region 1 (C1 domain) superfamily
- GTPase activator
- protein binding
- GTPase Activating Protein domain
- Bin/Amphiphysin/Rvs domain
- GTPase-activator protein for Rho-like GTPases
- RhoGAP
- PDZ-domain binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- nonsyndromic cleft lip with or without cleft palate
- hepatitis
- prostate cancer
role in cell
- docetaxel resistance
- glycolysis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Arhgap29 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of small GTPase mediated signal transduction
- Rho protein signal transduction
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- macromolecular complex
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- GTPase activator activity
- PDZ domain binding