PPM1B
PPM1B Gene Summary
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase has been shown to dephosphorylate cyclin-dependent kinases (CDKs), and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to cause cell-growth arrest or cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional transcript variants have been described, but currently do not represent full-length sequences. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | PPM1B |
| Official Name | protein phosphatase, Mg2+/Mn2+ dependent 1B [Source:HGNC Symbol;Acc:HGNC:9276] |
| Ensembl ID | ENSG00000138032 |
| Bio databases IDs | |
| Aliases | protein phosphatase, Mg2+/Mn2+ dependent 1B, protein phosphatase 2C, beta isoform |
| Synonyms | Pp2c2,PP2CB,PP2CBETA,PP2C-beta-X,PP2C-β,PP2C-β-X,PPC2BETAX,protein phosphatase 1B, magnesium dependent, beta isoform,protein phosphatase 1B, magnesium dependent, β isoform,protein phosphatase, Mg2+/Mn2+ dependent 1B,protein phosphatase, Mg2+/Mn2+ dependent, 1B |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Protein phosphatase 2C
- protein serine/threonine phosphatase
- phosphoprotein phosphatase
- phosphatase
- Protein serine/threonine phosphatase 2C, C-terminal domain
- protein binding
- Serine/threonine phosphatases, family 2C, catalytic domain
- PP2Cc
Pathways
Biological processes and signaling networks where the PPM1B gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- NCOA1
- KDR
- EGLN3
- EGFR
- VCP
- HIP1R
- KDF1
- SCGN
- PABPC4
- NANOG
disease
- Huntington disease
- tumorigenesis
- rotator cuff injury
- cholelithiasis
regulated by
- AGTR1
- progesterone
- Lmp1
- ESRRA
- tretinoin
- ESR1
- GABA
- SOX17
- ARID3A
- TP53
regulates
- TP53
- NFkB (complex)
- NFKB1
- CDK2
- HBEGF
- PRMT5
- CDK6
- PPP1R12A
- DYRK1A
- CDK9
role in cell
- expression in
- survival
- phosphorylation in
- activation in
- colony formation by
- oligomerization in
- cell survival
- aggregation in
- dimethylation in
- dephosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- cytosol
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the PPM1B gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- peptidyl-threonine dephosphorylation
- protein dephosphorylation
- positive regulation of canonical Wnt receptor signaling pathway
- negative regulation of I-kappaB kinase/NF-kappaB cascade
- N-terminal protein myristoylation
- negative regulation of defense response to virus
- negative regulation of interferon-beta production
CELLULAR COMPONENT
Where in the cell the gene product is active
- nucleus
- membrane
- cytosol
- nucleolus
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein serine/threonine phosphatase activity
- magnesium ion binding
- protein binding
- manganese ion binding
- myosin phosphatase activity