Ppm1b Gene Summary [Mouse]
Predicted to enable protein serine/threonine phosphatase activity. Involved in N-terminal protein myristoylation and protein dephosphorylation. Located in cytosol and membrane. Is expressed in several structures, including blastocyst; early embryo; gonad; liver; and lung. Orthologous to human PPM1B (protein phosphatase, Mg2+/Mn2+ dependent 1B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ppm1b |
| Official Name | protein phosphatase 1B, magnesium dependent, beta isoform [Source:MGI Symbol;Acc:MGI:101841] |
| Ensembl ID | ENSMUSG00000061130 |
| Bio databases IDs | |
| Aliases | protein phosphatase 1B, magnesium dependent, beta isoform |
| Synonyms | Pp2c2, PP2CB, PP2CBETA, PP2C-beta-X, PP2C-β, PP2C-β-X, PPC2BETAX, protein phosphatase 1B, magnesium dependent, beta isoform, protein phosphatase 1B, magnesium dependent, β isoform, protein phosphatase, Mg2+/Mn2+ dependent 1B, protein phosphatase, Mg2+/Mn2+ dependent, 1B |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ppm1b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Protein phosphatase 2C
- protein serine/threonine phosphatase
- phosphoprotein phosphatase
- phosphatase
- Protein serine/threonine phosphatase 2C, C-terminal domain
- protein binding
- Serine/threonine phosphatases, family 2C, catalytic domain
- PP2Cc
Pathways
Biological processes and signaling networks where the Ppm1b gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Huntington disease
- tumorigenesis
- rotator cuff injury
- cholelithiasis
role in cell
- expression in
- survival
- phosphorylation in
- activation in
- colony formation by
- oligomerization in
- cell survival
- aggregation in
- dimethylation in
- dephosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- cytosol
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ppm1b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- peptidyl-threonine dephosphorylation
- protein dephosphorylation
- positive regulation of canonical Wnt receptor signaling pathway
- negative regulation of I-kappaB kinase/NF-kappaB cascade
- N-terminal protein myristoylation
- negative regulation of defense response to virus
- negative regulation of interferon-beta production
Cellular Component
Where in the cell the gene product is active
- nucleus
- membrane
- cytosol
- nucleolus
Molecular Function
What the gene product does at the molecular level
- protein serine/threonine phosphatase activity
- magnesium ion binding
- protein binding
- manganese ion binding
- myosin phosphatase activity