PPP1R12A Gene Summary [Human]
Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound, active form of RhoA (GTP.RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC. Rho-associated kinase (Rho-kinase), which is activated by GTP. RhoA, phosphorylated MBS and consequently inactivated myosin phosphatase. Overexpression of RhoA or activated RhoA in NIH 3T3 cells increased phosphorylation of MBS and MLC. Thus, Rho appears to inhibit myosin phosphatase through the action of Rho-kinase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009]
Details
| Type | Protein Coding |
| Official Symbol | PPP1R12A |
| Official Name | protein phosphatase 1 regulatory subunit 12A [Source:HGNC Symbol;Acc:HGNC:7618] |
| Ensembl ID | ENSG00000058272 |
| Bio databases IDs | |
| Aliases | protein phosphatase 1 regulatory subunit 12A, myosin phosphatase-targeting subunit 1, myosin binding subunit |
| Synonyms | 1200015F06Rik, 5730577I22Rik, AA792106, AV099298, D10Ertd625e, GUBS, M110, M130, MBS, MBS130, MBSP, Mypt, MYPT1, protein phosphatase 1 regulatory subunit 12A, protein phosphatase 1, regulatory subunit 12A |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PPP1R12A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cGMP-dependent protein kinase interacting domain
- Ankyrin repeats (many copies)
- protein kinase binding
- enzyme inhibitor activity
- Ankyrin repeats (3 copies)
- leucine zipper domain
- protein binding
- IPD_PPP1R12
- phosphatase regulator
- Ankyrin repeat
- myosin-binding domain
- protein phosphatase
- phosphatase
- ankyrin repeats
Pathways
Biological processes and signaling networks where the PPP1R12A gene in human plays a role, providing insight into its function and relevance in health or disease.
- Actin Cytoskeleton Signaling
- Actin Nucleation by ARP-WASP Complex
- Cardiac β-adrenergic Signaling
- CCR3 Signaling in Eosinophils
- CDK5 Signaling
- Cellular Effects of Sildenafil (Viagra)
- Chemokine Signaling
- Dopamine Receptor Signaling
- Dopamine-DARPP32 Feedback in cAMP Signaling
- ERK/MAPK Signaling
- HIPPO signaling
- ILK Signaling
- Insulin Receptor Signaling
- Integrin Signaling
- Production of Nitric Oxide and Reactive Oxygen Species in Macrophages
- Regulation of Actin-based Motility by Rho
- RhoA Signaling
- RhoGDI Signaling
- Serotonin Receptor Signaling
- Thrombin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- genitourinary and/or brain malformation syndrome
- tumorigenesis
- hereditary disorder
- myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis
- gestational diabetes mellitus
- neonatal late-onset sepsis
role in cell
- proliferation
- expression in
- phosphorylation in
- segregation
- epithelial-mesenchymal transition
- response by
- adhesion
- mitosis
- binding in
- dimethylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell periphery
- actin cytoskeleton
- Nucleus
- Plasma Membrane
- centrosome
- actomyosin filament
- sarcomere
- cytosol
- nucleoplasm
- nucleoli
- myofibrils
- Z line
- cortical actin filaments
- actin stress fibers
- cleavage furrow
- kinetochores
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PPP1R12A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of catalytic activity
- centrosome cycle
- regulation of myosin-light-chain-phosphatase activity
- signal transduction
- positive regulation of myosin-light-chain-phosphatase activity
- protein dephosphorylation
- cellular response to xenobiotic stimulus
- regulation of cell adhesion
- positive regulation of transcription from RNA polymerase II promoter
- regulation of nucleocytoplasmic transport
- mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- kinetochore
- nucleolus
- plasma membrane
- nucleoplasm
- Z disc
- centrosome
- contractile fiber
- focal adhesion
- cytoplasm
- stress fiber
- actin cytoskeleton
- cytosol
- PTW/PP1 phosphatase complex
- A band
Molecular Function
What the gene product does at the molecular level
- phosphatase regulator activity
- protein kinase binding
- protein binding
- enzyme inhibitor activity
- 14-3-3 protein binding