ZGRF1 Gene Summary [Human]
The encoded protein contains GRF zinc finger (zf-GRF) and transmembrane domains. GRF zinc fingers are found in a number of DNA-binding proteins. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2017]
Details
| Type | Protein Coding |
| Official Symbol | ZGRF1 |
| Official Name | zinc finger GRF-type containing 1 [Source:HGNC Symbol;Acc:HGNC:25654] |
| Ensembl ID | ENSG00000138658 |
| Bio databases IDs | |
| Aliases | zinc finger GRF-type containing 1 |
| Synonyms | 4930422G04Rik, C4orf21, FLJ11331, LOC100363957, LOC686897, LOC91431, RGD1305834, zinc finger GRF-type containing 1, zinc finger, GRF-type containing 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ZGRF1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- N-terminal helicase domain of the DEAD-box helicase superfamily
- GRF zinc finger
- enzyme
- protein binding
- P-loop containing Nucleoside Triphosphate Hydrolases
- AAA domain
- DNA helicase
- Protein of unknown function (DUF2439)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ZGRF1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA duplex unwinding
- recombinational repair
- double-strand break repair
Cellular Component
Where in the cell the gene product is active
- nucleus
- site of double-strand break
Molecular Function
What the gene product does at the molecular level
- ATP binding
- zinc ion binding
- protein binding
- 5'-3' DNA helicase activity
- hydrolase activity
- isomerase activity