RNF185 Gene Summary [Human]
Enables ubiquitin binding activity; ubiquitin protein ligase activity; and ubiquitin-like protein conjugating enzyme binding activity. Involved in positive regulation of ERAD pathway; protein autoubiquitination; and ubiquitin-dependent ERAD pathway. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Retained Intron |
| Official Symbol | RNF185 |
| Official Name | ring finger protein 185 [Source:HGNC Symbol;Acc:HGNC:26783] |
| Ensembl ID | ENSG00000138942 |
| Bio databases IDs | |
| Aliases | ring finger protein 185, hypothetical protein FLJ38628 |
| Synonyms | ring finger protein 185 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RNF185 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase activity
- zinc finger of C3HC4-type, RING
- enzyme binding
- ubiquitin binding
- enzyme
- Ring finger domain
- protein binding
- binding protein
- RING-type zinc-finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RNF185 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transmembrane transport
- positive regulation of innate immune response
- innate immune response
- autophagy
- positive regulation of type I interferon-mediated signaling pathway
- defense response to virus
- protein K27-linked ubiquitination
- ubiquitin-dependent protein catabolic process
- protein autoubiquitination
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- endoplasmic reticulum
- mitochondrial outer membrane
Molecular Function
What the gene product does at the molecular level
- small protein conjugating enzyme binding
- protein binding
- ubiquitin binding
- metal ion binding