AMFR Gene Summary [Human]
This locus encodes a glycosylated transmembrane receptor. Its ligand, autocrine motility factor, is a tumor motility-stimulating protein secreted by tumor cells. The encoded receptor is also a member of the E3 ubiquitin ligase family of proteins. It catalyzes ubiquitination and endoplasmic reticulum-associated degradation of specific proteins. [provided by RefSeq, Feb 2012]
Details
| Type | Protein Coding |
| Official Symbol | AMFR |
| Official Name | autocrine motility factor receptor [Source:HGNC Symbol;Acc:HGNC:463] |
| Ensembl ID | ENSG00000159461 |
| Bio databases IDs | |
| Aliases | autocrine motility factor receptor |
| Synonyms | autocrine motility factor receptor, GP78, RNF45, SPG89 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human AMFR often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- UBA domain-like superfamily
- signaling receptor activity
- protease binding
- ubiquitin protein ligase activity
- protein binding activity, bridging
- Ring finger domain
- protein binding
- identical protein binding
- RING-like zinc finger
- E3 gp78 Ube2g2-binding region (G2BR)
- multiple membrane-spanning domain
- binding protein
- RING-type zinc-finger
- cytoplasmic domain
- Ring finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- ubiquitin-protein transferase activity
- transmembrane domain
- cytosolic tail domain
- chaperone binding
- transmembrane receptor
- RING-H2 zinc finger domain
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Pathways
Biological processes and signaling networks where the AMFR gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- autosomal recessive spastic paraplegia type 89
- major depression
- hereditary spastic paraplegia
- ovalbumin-induced asthma
- metastasis
- breast carcinoma
- prostate cancer
- experimentally-induced asthma
role in cell
- apoptosis
- survival
- expression in
- production in
- phosphorylation in
- proliferation
- degradation in
- cellular infiltration by
- accumulation
- accumulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- cell surface
- perinuclear region
- cellular membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- growth cone
- smooth endoplasmatic reticulum
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human AMFR gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein K48-linked ubiquitination
- signal transduction
- protein polyubiquitination
- NIK/NF-kappaB cascade
- protein K27-linked ubiquitination
- ubiquitin-dependent protein catabolic process
- learning or memory
- negative regulation of canonical Wnt receptor signaling pathway
- endoplasmic reticulum unfolded protein response
- regulation of SREBP-mediated signaling pathway
- Wnt receptor signaling pathway
- protein autoubiquitination
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- growth cone
- dendrite
- perinuclear region of cytoplasm
- ubiquitin ligase complex
- membrane
- cytosol
- Golgi apparatus
- endoplasmic reticulum
- macromolecular complex
- neuronal cell body
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- identical protein binding
- protein binding
- ubiquitin binding
- metal ion binding
- chaperone binding
- ubiquitin-ubiquitin ligase activity
- signaling receptor activity
- protein binding, bridging