HIGD1A Gene Summary [Human]
Acts upstream of or within negative regulation of apoptotic process. Located in mitochondrion and nucleoplasm. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | HIGD1A |
| Official Name | HIG1 hypoxia inducible domain family member 1A [Source:HGNC Symbol;Acc:HGNC:29527] |
| Ensembl ID | ENSG00000181061 |
| Bio databases IDs | |
| Aliases | HIG1 hypoxia inducible domain family member 1A, hypoxia inducible gene 1 |
| Synonyms | 2210020B17Rik, 7420700H20Rik, HIG1, HIG1 domain family, member 1A, HIG1 hypoxia inducible domain family member 1A, HIG1 hypoxia inducible domain family, member 1A, HIMP1, Hypoxia-induced gene 1, RCF1a |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human HIGD1A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Hypoxia induced protein conserved region
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- Parkinson disease
- colon cancer
role in cell
- activation in
- ubiquitination in
- apoptosis
- accumulation in
- response by
- dysfunction
- dysfunction in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- cellular membrane
- Nucleus
- Mitochondria
- mitochondrial membrane
- mitochondrial inner membrane
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human HIGD1A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of apoptotic process
- mitochondrial respiratory chain supercomplex assembly
Cellular Component
Where in the cell the gene product is active
- mitochondrion
- macromolecular complex
- mitochondrial inner membrane
- respiratory chain
- nucleoplasm