NR4A2 Gene Summary [Human]
This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | NR4A2 |
| Official Name | nuclear receptor subfamily 4 group A member 2 [Source:HGNC Symbol;Acc:HGNC:7981] |
| Ensembl ID | ENSG00000153234 |
| Bio databases IDs | |
| Aliases | nuclear receptor subfamily 4 group A member 2 |
| Synonyms | HZF-3, IDLDP, NOT, nuclear receptor subfamily 4 group A member 2, nuclear receptor subfamily 4, group A, member 2, NURR1, Nurr2, RNR-1, TINOR, TINUR |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NR4A2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- A-box
- ligand-dependent nuclear receptor interactor
- DNA binding domain
- DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
- beta-catenin binding
- nucleic acid binding
- helical domain
- AF-2 transcription activation domain
- protein binding
- sequence-specific DNA binding
- DNA binding
- Box I domain
- nuclear receptor ligand binding domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- AF-1 domain
- ligand-binding domain
- double-stranded DNA binding
- ligand-dependent nuclear receptor
- heterodimerization domain
- retinoid X receptor binding
- Ligand-binding domain of nuclear hormone receptor
- protein heterodimerization
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cardiovascular disorder
- neoplasia
- COVID-19
- Parkinson disease
- breast cancer
- gastric cancer
- psoriasis
- familial Parkinson disease
- complex neurodevelopmental disorder
- osteoarthritis
role in cell
- expression in
- quantity
- growth
- damage in
- proliferation
- production in
- degradation in
- loss
- degeneration
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- cytosol
- nucleoplasm
- nuclear speckles
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NR4A2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- dopamine biosynthetic process
- post-embryonic development
- neuron maturation
- central nervous system projection neuron axonogenesis
- transcription from RNA polymerase II promoter
- adult locomotory behavior
- central nervous system neuron differentiation
- fat cell differentiation
- positive regulation of transcription from RNA polymerase II promoter
- negative regulation of neuron apoptotic process
- negative regulation of transcription from RNA polymerase II promoter
- neuron migration
- response to hypoxia
- cellular response to corticotropin-releasing hormone stimulus
- canonical Wnt receptor signaling pathway
- general adaptation syndrome
- neuron apoptotic process
- intracellular receptor mediated signaling pathway
- transcription, DNA-dependent
- regulation of respiratory gaseous exchange
- habenula development
- regulation of transcription from RNA polymerase II promoter
- response to amphetamine
- dopaminergic neuron differentiation
- regulation of dopamine metabolic process
- cellular response to oxidative stress
- negative regulation of apoptotic signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcription factor complex
- cytoplasm
- nuclear speck
- macromolecular complex
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- zinc ion binding
- protein binding
- protein heterodimerization activity
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- beta-catenin binding
- glucocorticoid receptor binding
- retinoid X receptor binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity