GABARAP Gene Summary [Human]
Gamma-aminobutyric acid A receptors [GABA(A) receptors] are ligand-gated chloride channels that mediate inhibitory neurotransmission. This gene encodes GABA(A) receptor-associated protein, which is highly positively charged in its N-terminus and shares sequence similarity with light chain-3 of microtubule-associated proteins 1A and 1B. This protein clusters neurotransmitter receptors by mediating interaction with the cytoskeleton. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | GABARAP |
| Official Name | GABA type A receptor-associated protein [Source:HGNC Symbol;Acc:HGNC:4067] |
| Ensembl ID | ENSG00000170296 |
| Bio databases IDs | |
| Aliases | GABA type A receptor-associated protein |
| Synonyms | ATG8A, GABARAP-a, GABARAP-I, GABARAP-II, GABA type A receptor-associated protein, gamma-aminobutyric acid receptor associated protein, MM46, γ-aminobutyric acid receptor associated protein |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GABARAP often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- beta-tubulin binding
- microtubule binding
- ubiquitin protein ligase binding
- tubulin binding domain
- Ubl1_cv_Nsp3_N-like
- phosphatidylethanolamine binding
- protein binding
- receptor binding
- transporter
Pathways
Biological processes and signaling networks where the GABARAP gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- productive infection by HIV-1
role in cell
- apoptosis
- growth
- expression in
- proliferation
- activation in
- generation in
- loss
- organization
- stabilization
- fusion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubule fractions
- intracellular membrane-bounded organelle
- centriolar satellite
- organelle
- somatodendritic region
- perinuclear region
- actin cytoskeleton
- Plasma Membrane
- lysosome
- Golgi Apparatus
- axonemes
- cytosol
- sperm midpiece
- axon initial segments
- synapse
- autophagic vacuoles
- autolysosomes
- smooth endoplasmatic reticulum
- perikaryon
- smooth endoplasmic reticulum fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GABARAP gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- autophagic vacuole assembly
- protein targeting
- regulation of Rac protein signal transduction
- protein transport
- synaptic transmission
- microtubule cytoskeleton organization
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process
- induction of apoptosis via death domain receptors
- mitochondrion degradation
- cellular response to nitrogen starvation
Cellular Component
Where in the cell the gene product is active
- smooth endoplasmic reticulum
- Golgi membrane
- synapse
- axoneme
- autophagic vacuole
- autophagic vacuole membrane
- microtubule associated complex
- plasma membrane
- lysosome
- microtubule
- sperm midpiece
- actin cytoskeleton
- cytosol
- cytoplasmic vesicle
Molecular Function
What the gene product does at the molecular level
- phosphatidylethanolamine binding
- protein binding
- ubiquitin protein ligase binding
- beta-tubulin binding
- GABA receptor binding
- microtubule binding