DUOX2 Gene Summary [Human]
The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes this encoded protein and DUOX1. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | DUOX2 |
| Official Name | dual oxidase 2 [Source:HGNC Symbol;Acc:HGNC:13273] |
| Ensembl ID | ENSG00000140279 |
| Bio databases IDs | |
| Aliases | dual oxidase 2, dual oxidase-like domains 2, nicotinamide adenine dinucleotide phosphate oxidase, flavoprotein NADPH oxidase, NADPH thyroid oxidase 2, NADH/NADPH thyroid oxidase p138-tox, NADPH oxidase/peroxidase DUOX2 |
| Synonyms | A430065P05, A430065P05Rik, dual oxidase 2, LNOX2, NOXEF2, P138-TOX, TDH6, THOX2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DUOX2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FNR_like
- EF-hand, calcium binding motif
- EF-hand domain pair
- calcium ion binding
- Cytochrome_b_N
- EFh
- Animal haem peroxidase
- enzyme
- Animal heme peroxidases and related proteins
- protein binding
- EFh_PI-PLC
- EF-hand domain
- EF hand
- NADPH oxidase
- Oxidoreductase NAD-binding domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- osteoarthritis
- congenital hypothyroidism
- thyroid dyshormonogenesis 6
- anaplastic thyroid carcinoma
- anaplastic thyroid cancer
- epithelial thyroid cancer
- rheumatoid arthritis
- coronary artery disease
- hereditary disorder
- Wallerian degeneration
role in cell
- generation in
- acidification
- acidification in
- activation in
- expression in
- phosphorylation in
- proliferation
- number
- fertilization
- shedding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- intracellular space
- apical compartment
- Endoplasmic Reticulum
- cytosol
- cell membrane leading edge
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DUOX2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of wound healing
- thyroid hormone generation
- response to cAMP
- response to virus
- superoxide anion generation
- defense response
- cuticle development
- hormone biosynthetic process
- hydrogen peroxide catabolic process
- response to oxidative stress
- cytokine-mediated signaling pathway
- hydrogen peroxide biosynthetic process
- positive regulation of cell motility
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- anchoring junction
- apical part of cell
- NADPH oxidase complex
- cell leading edge
- cytosol
- endoplasmic reticulum
- apical plasma membrane
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- peroxidase activity
- protein binding
- calcium ion binding
- NAD(P)H oxidase activity
- superoxide-generating NADPH oxidase activity
- heme binding