FGF7

FGF7 Gene Summary

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is a potent epithelial cell-specific growth factor, whose mitogenic activity is predominantly exhibited in keratinocytes but not in fibroblasts and endothelial cells. Studies of mouse and rat homologs of this gene implicated roles in morphogenesis of epithelium, reepithelialization of wounds, hair development and early lung organogenesis. [provided by RefSeq, Jul 2008]

Details

Type
Protein Coding
Official Symbol
FGF7
Official Name
fibroblast growth factor 7 [Source:HGNC Symbol;Acc:HGNC:3685]
Ensembl ID
ENSG00000140285
Bio databases IDs NCBI: 2252 Ensembl: ENSG00000140285
Aliases fibroblast growth factor 7, keratinocyte growth factor
Synonyms
Fgf5b,fibroblast growth factor 7,HBGF-7,keratinocyte growth factor,KGF,KGF-1,KGF-7,KGF/FGF7
Species
Human, Homo sapiens

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • beta-trefoil_FGF
  • type 2 fibroblast growth factor receptor binding
  • chemoattractant
  • protein binding
  • loop domain
  • heparin binding
  • growth factor

Pathways

Biological processes and signaling networks where the FGF7 gene plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
  • DCN
  • HNF4A
  • FGFR3
  • FGFR2
  • FGFR1
  • COL1A2
  • Collagen type I (complex)
  • Collagen type I
  • HSPG2
  • COL1A1
disease
  • adenoma formation
  • epithelial neoplasia
  • benign neoplasia
  • epithelial cancer
  • cancer
  • breast cancer
  • seizures
  • epileptic seizure
  • weight loss
  • papillary thyroid carcinoma
regulated by
  • AGT
  • KRAS
  • CG
  • TGFB1
  • tetradecanoylphorbol acetate
  • corticosterone
  • chondroitin sulfate B
  • TGFA
  • BRAF
  • PTEN
regulates
  • histone H3
  • Ca2+
  • MMP
  • MMP2
  • CXCL8
  • TP53
  • ERK
  • p38 MAPK
  • MAPK3
  • MAPK1
role in cell
  • degradation
  • growth
  • activation in
  • quantity
  • expression in
  • migration
  • phosphorylation in
  • proliferation
  • cell death
  • degradation in

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Extracellular Space
  • Cytoplasm
  • cell surface
  • postsynaptic region
  • Golgi Apparatus
  • synapse

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the FGF7 gene, providing context for its role in the cell.

BIOLOGICAL PROCESS

Functions and activities the gene product is involved in
  • protein localization at cell surface
  • positive chemotaxis
  • secretion by lung epithelial cell involved in lung growth
  • positive regulation of cell proliferation
  • response to wounding
  • epidermis development
  • fibroblast growth factor receptor signaling pathway
  • regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
  • branching involved in salivary gland morphogenesis
  • positive regulation of epithelial cell proliferation involved in lung morphogenesis
  • positive regulation of keratinocyte proliferation
  • positive regulation of cell division
  • positive regulation of transcription, DNA-dependent
  • positive regulation of keratinocyte migration
  • positive regulation of epithelial cell proliferation
  • positive regulation of peptidyl-tyrosine phosphorylation
  • lung development
  • signal transduction
  • positive regulation of MAPK cascade
  • organ morphogenesis
  • positive regulation of gene expression
  • myoblast proliferation
  • cell differentiation
  • endothelial cell proliferation
  • hair follicle morphogenesis
  • positive regulation of myoblast proliferation
  • positive regulation of endothelial cell proliferation
  • regulation of cell migration
  • actin cytoskeleton organization
  • mesenchymal cell proliferation

CELLULAR COMPONENT

Where in the cell the gene product is active
  • extracellular space
  • cytoplasm
  • Golgi apparatus
  • extracellular region

MOLECULAR FUNCTION

What the gene product does at the molecular level
  • growth factor activity
  • protein binding
  • chemoattractant activity
  • heparin binding
  • type 2 fibroblast growth factor receptor binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.