GTF2A2 Gene Summary [Human]
Accurate transcription initiation on TATA-containing class II genes involves the ordered assembly of RNA polymerase II (POLR2A; MIM 180660) and the general initiation factors TFIIA, TFIIB (MIM 189963), TFIID (MIM 313650), TFIIE (MIM 189962), TFIIF (MIM 189968), TFIIG/TFIIJ, and TFIIH (MIM 189972). The first step involves recognition of the TATA element by the TATA-binding subunit (TBP; MIM 600075) and may be regulated by TFIIA, a factor that interacts with both TBP and a TBP-associated factor (TAF; MIM 600475) in TFIID. TFIIA has 2 subunits (43 and 12 kD) in yeast and 3 subunits in higher eukaryotes. In HeLa extracts, it consists of a 35-kD alpha subunit and a 19-kD beta subunit encoded by the N- and C-terminal regions of GTF2A1 (MIM 600520), respectively, and a 12-kD gamma subunit encoded by GTF2A2 (DeJong et al., 1995 [PubMed 7724559]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | GTF2A2 |
| Official Name | general transcription factor IIA subunit 2 [Source:HGNC Symbol;Acc:HGNC:4647] |
| Ensembl ID | ENSG00000140307 |
| Bio databases IDs | |
| Aliases | general transcription factor IIA subunit 2, TFIIA gamma subunit |
| Synonyms | general transcription factor 2A subunit 2, general transcription factor II A, 2, general transcription factor IIA subunit 2, HsT18745, T18745, TF2A2, TFIIA, TFIIA-12, Tfiia2, TFIIA-gamma, TFIIAS, TFIIA-γ, TFIIG |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GTF2A2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- Gamma subunit of transcription initiation factor IIA, N-terminal helical domain
- protein homodimerization
- transcription factor binding
- protein binding
- general RNA polymerase II transcription factor
- TATA-binding protein binding
- protein heterodimerization
- Gamma subunit of transcription initiation factor IIA, C-terminal domain
Pathways
Biological processes and signaling networks where the GTF2A2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cell junction
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GTF2A2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA polymerase II transcriptional preinitiation complex assembly
- positive regulation of transcription initiation from RNA polymerase II promoter
- transcription from RNA polymerase II promoter
- positive regulation of transcription from RNA polymerase II promoter
- transcription initiation from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcription factor TFIID complex
- cell junction
- transcription factor TFIIA complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein homodimerization activity
- protein heterodimerization activity
- general RNA polymerase II transcription factor activity
- RNA polymerase II basal transcription factor binding
- TBP-class protein binding