GTF2B Gene Summary [Human]
This gene encodes the general transcription factor IIB, one of the ubiquitous factors required for transcription initiation by RNA polymerase II. The protein localizes to the nucleus where it forms a complex (the DAB complex) with transcription factors IID and IIA. Transcription factor IIB serves as a bridge between IID, the factor which initially recognizes the promoter sequence, and RNA polymerase II. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | GTF2B |
| Official Name | general transcription factor IIB [Source:HGNC Symbol;Acc:HGNC:4648] |
| Ensembl ID | ENSG00000137947 |
| Bio databases IDs | |
| Aliases | general transcription factor IIB |
| Synonyms | general transcription factor IIB, TF2B, TFIIB |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GTF2B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Transcription factor TFIIB repeat
- transcription regulator
- Cyclin box fold superfamily
- transcription factor binding
- chromatin binding
- enzyme
- domain present in cyclins, TFIIB and Retinoblastoma
- general RNA polymerase II transcription factor
- B-finger domain
- TATA-binding protein binding
- zinc ion binding
- TFIIB zinc-binding
- nucleic acid binding
- TBP binding domain
- alpha helix
- enzyme binding
- protein binding
- thyroid hormone receptor binding
- sequence-specific DNA binding
- DNA binding
- N-acetyltransferase
- double-stranded DNA binding
- RNA polymerase II binding domain
- zinc finger domain
- acetyltransferase
Pathways
Biological processes and signaling networks where the GTF2B gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertension
- insomnia
- Waldenström macroglobulinemia
- essential hypertension
role in cell
- growth
- development
- assembly
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- detergent-insoluble fractions
- metaphase plate
- chromosome
- nucleoplasm
- nuclear bodies
- germinal vesicles
- kinetochores
- plasma
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GTF2B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- viral transcription
- spindle assembly
- RNA polymerase II transcriptional preinitiation complex assembly
- chromatin remodeling
- transcriptional start site selection at RNA polymerase II promoter
- meiotic sister chromatid cohesion
- transcription from RNA polymerase II promoter
- protein acetylation
- transcription initiation from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- transcription factor TFIID complex
- cell division site
- protein-DNA complex
- germinal vesicle
- kinetochore
- chromosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- histone acetyltransferase activity
- zinc ion binding
- protein binding
- acetyltransferase activity
- RNA polymerase II core promoter sequence-specific DNA binding
- general RNA polymerase II transcription factor activity
- TBP-class protein binding
- RNA polymerase II core binding
- thyroid hormone receptor binding