PAPOLB Gene Summary [Human]
Predicted to enable polynucleotide adenylyltransferase activity. Predicted to be involved in mRNA polyadenylation. Predicted to be located in endoplasmic reticulum. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | PAPOLB |
| Official Name | poly(A) polymerase beta [Source:HGNC Symbol;Acc:HGNC:15970] |
| Ensembl ID | ENSG00000218823 |
| Bio databases IDs | |
| Aliases | poly(A) polymerase beta |
| Synonyms | PAP, Paplob, Papola-ps, PAPT, Plap-ps, poly(A) polymerase beta, poly (A) polymerase beta (testis specific), poly(A) polymerase β, poly (A) polymerase β (testis specific), TPAP |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PAPOLB often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Poly(A) polymerase central domain
- Poly(A) polymerase predicted RNA binding domain
- Nucleotidyltransferase (NT) domain of DNA polymerase beta and similar proteins
- nucleotidyltransferase
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PAPOLB gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA 3'-end processing
- mRNA processing
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- RNA binding
- metal ion binding