KSR1 Gene Summary [Human]
Enables 14-3-3 protein binding activity; ATP binding activity; and protein C-terminus binding activity. Involved in positive regulation of MAPK cascade. Located in endoplasmic reticulum and membrane. Part of protein-containing complex. Implicated in breast adenocarcinoma. Biomarker of breast cancer. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | KSR1 |
| Official Name | kinase suppressor of ras 1 [Source:HGNC Symbol;Acc:HGNC:6465] |
| Ensembl ID | ENSG00000141068 |
| Bio databases IDs | |
| Aliases | kinase suppressor of ras 1 |
| Synonyms | AW492498, Ceramide-activated protein kinase, D11Bhm183e, D11Bhm184e, hb, kinase suppressor of ras 1, KSR, mKSR1, RSU2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human KSR1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- protein kinase
- ATP binding
- heat shock protein binding
- Protein kinase domain
- proline rich domain
- zinc finger homology domain
- SAM like domain present in kinase suppressor RAS 1
- Caspase 3 cleavage site
- protein kinase C conserved region 1 (C1 domain) superfamily
- Kinase suppressor RAS 1 N-terminal helical hairpin
- chaperone binding
- Tyrosine kinase, catalytic domain
- cysteine rich domain
- Protein kinase (unclassified specificity)
- protein kinase binding
- catalytic domain
- Protein tyrosine and serine/threonine kinase
- CR1 domain
- serine/threonine kinase domain
- protein binding
- phosphorylation site
- MAP-kinase scaffold protein
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- serine threonine rich domain
Pathways
Biological processes and signaling networks where the KSR1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- Crohn disease
- rheumatoid arthritis
- alopecia
- endometriosis
- Waldenström macroglobulinemia
- inflammatory bowel disease
- arthritis
- blistering
- systemic lupus erythematosus
role in cell
- apoptosis
- activation
- activation in
- survival
- phosphorylation in
- proliferation
- expression in
- migration
- formation
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- caveolae-derived endocytic vesicles
- intracellular membrane-bounded organelle
- cellular membrane
- Nucleus
- Endoplasmic Reticulum
- cytosol
- perikaryon
- dendrites
- cytoplasmic fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human KSR1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- MAPK cascade
- regulation of MAP kinase activity
- Ras protein signal transduction
- positive regulation of MAPK cascade
- regulation of cell proliferation
- cAMP-mediated signaling
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- cytoplasm
- intracellular membrane-bounded organelle
- membrane
- ruffle membrane
- cytosol
- macromolecular complex
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- metal ion binding
- protein kinase activity
- MAP-kinase scaffold activity
- protein serine/threonine kinase activity
- 14-3-3 protein binding