MINK1 Gene Summary [Human]
This gene encodes a serine/threonine kinase belonging to the germinal center kinase (GCK) family. The protein is structurally similar to the kinases that are related to NIK and may belong to a distinct subfamily of NIK-related kinases within the GCK family. Studies of the mouse homolog indicate an up-regulation of expression in the course of postnatal mouse cerebral development and activation of the cJun N-terminal kinase (JNK) and the p38 pathways. [provided by RefSeq, Mar 2016]
Details
| Type | Protein Coding |
| Official Symbol | MINK1 |
| Official Name | misshapen like kinase 1 [Source:HGNC Symbol;Acc:HGNC:17565] |
| Ensembl ID | ENSG00000141503 |
| Bio databases IDs | |
| Aliases | misshapen like kinase 1, misshapen/NIK-related kinase |
| Synonyms | B55, LOC687705, MAP4K6, MEKKK 6, MINK, misshapen-like kinase 1, misshapen-like kinase 1 (zebrafish), YSK2, ZC3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MINK1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- catalytic domain
- Protein tyrosine and serine/threonine kinase
- CNH domain
- ATP binding
- protein binding
- Protein kinase domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the MINK1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- breast cancer
- sarcoma
- bleeding
- rheumatoid arthritis
- colorectal cancer
- acute coronary syndrome
- thrombocytopenia
- cerebral aneurysm
- multiple sclerosis
role in cell
- survival
- binding
- phosphorylation in
- formation
- adhesion
- migration
- motility
- cell spreading
- invasion
- aggregation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- perinuclear region
- postsynaptic region
- Golgi Apparatus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MINK1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of MAPK cascade
- regulation of cell-cell adhesion
- neuron projection morphogenesis
- synaptic transmission
- protein autophosphorylation
- JNK cascade
- brain development
- protein phosphorylation
- positive regulation of p38MAPK cascade
- dendrite morphogenesis
- MAPK cascade
- regulation of cell-matrix adhesion
- positive regulation of JNK cascade
- microvillus assembly
- regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
- regulation of cell migration
- actin cytoskeleton organization
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- dendrite
- extracellular vesicular exosome
- cytoplasm
- cytosol
- Golgi apparatus
- axon
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- protein kinase activity
- protein serine/threonine kinase activity