AGAP2 Gene Summary [Human]
The protein encoded by this gene belongs to the centaurin gamma-like family. It mediates anti-apoptotic effects of nerve growth factor by activating nuclear phosphoinositide 3-kinase. It is overexpressed in cancer cells, and promotes cancer cell invasion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
Details
| Type | Protein Coding |
| Official Symbol | AGAP2 |
| Official Name | ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 [Source:HGNC Symbol;Acc:HGNC:16921] |
| Ensembl ID | ENSG00000135439 |
| Bio databases IDs | |
| Aliases | ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 |
| Synonyms | ArfGAP with GTPase domain, ankyrin repeat and PH domain 2, CENTG1, cnt-g1, GGAP2, mKIAA0167, PIKE, Pike-l |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human AGAP2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein like domain
- Ankyrin repeats (many copies)
- Ras family
- ATP binding
- GTPase activator
- enzyme
- phosphoinositide 3-kinase regulator
- GTPase Activating Protein domain
- GTPase-activating protein (GAP) for the ADP ribosylation factors (ARFs)
- Arf-GAP domain
- Ankyrin repeat
- Ras of Complex, Roc, domain of DAPkinase
- Putative GTPase activating protein for Arf
- P-loop containing Nucleoside Triphosphate Hydrolases
- protein kinase binding
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- Ankyrin repeats (3 copies)
- GTPase
- protein binding
- Pleckstrin homology-like domain
- ionotropic glutamate receptor binding
- Ras subfamily of RAS small GTPases
- protein kinase activator
- GTP binding
- binding protein
- GTPase domain
- Putative GTP-ase activating proteins for the small GTPase, ARF
- Rab subfamily of small GTPases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- epithelial neoplasia
- cancer
- insulin resistance
- glioblastoma
- glioblastoma cancer
- prostate cancer
- prostatic neoplasia
- pelvic cancer
- urogenital cancer
role in cell
- expression in
- migration
- phosphorylation in
- apoptosis
- activation in
- proliferation
- cell viability
- cell death
- arborization
- size
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- detergent-insoluble membrane fraction
- detergent-soluble membrane fractions
- glutaminergic synapse
- Cytoplasm
- postsynaptic region
- focal adhesions
- endosomes
- Flemming body
- cytosol
- plasma membrane extracellular face
- nucleoplasm
- dendrites
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human AGAP2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of protein kinase activity
- protein transport
- endosomal transport
- negative regulation of protein catabolic process
- actin cytoskeleton organization
- negative regulation of neuron apoptotic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- endosome
- cytoplasm
- membrane
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein kinase binding
- ATP binding
- protein binding
- phosphatidylinositol 3-kinase regulator activity
- metal ion binding
- protein kinase activator activity
- GTPase activity
- GTPase activator activity